Biologic variability of C-reactive protein: Is the available information reliable?

被引:39
作者
Braga, Federica [1 ]
Panteghini, Mauro [1 ]
机构
[1] Univ Milan, Ctr Interdipartimentale Riferibilita Metrol Med L, Milan, Italy
关键词
Biologic variability; C-reactive protein; Cardiovascular disease; PUBLIC-HEALTH PRACTICE; CARDIOVASCULAR-DISEASE; REFERENCE INTERVALS; MARKERS; SERUM; INFLAMMATION; PLASMA; DISTRIBUTIONS; QUALITY; ADULTS;
D O I
10.1016/j.cca.2012.04.010
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Background: C-reactive protein (CRP) is recognized as a marker of cardiovascular risk The biologic variability of CRP is crucial to understanding its significance in estimation of individual risk and subsequent changes in serial analyses. Methods: We systematically reviewed publications on biologic variation of CRP to evaluate the consistency of available data. Data was evaluated with attention to number and type of enrolled subjects, duration of study, frequency of sample collection, sample type, sample storage, analytical methodology, assay sensitivity and statistical analysis. Results: A total of eleven studies on CRP biologic variability were recruited from literature. The majority of studies were limited by choice of analytic methodology, population selection, protocol application, and statistical analysis. Unfortunately, the only study that fulfilled all major pre-analytical, analytical and post-analytical requirements derived biologic variability from logarithmically transformed data, thus making application to clinical practice difficult. Conclusions: There is a paucity of robust data on biologic CRP variability in serum. It is obvious that additional well defined studies are needed to define reliable values of reference change values and of number of samples required to estimate the individual's cardiovascular risk by CRP. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码:1179 / 1183
页数:5
相关论文
共 33 条
[1]  
[Anonymous], 2001, Biological variation: from principles to practice
[2]   Diet and lifestyle are associated with serum C-reactive proteins concentrations in a population-based study [J].
Bertran, N ;
Camps, J ;
Fernandez-Ballart, J ;
Arija, V ;
Ferre, N ;
Tous, M ;
Simo, D ;
Murphy, MM ;
Vilella, E ;
Joven, J .
JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 2005, 145 (01) :41-46
[3]   Biological variability of glycated hemoglobin [J].
Braga, Federica ;
Dolci, Alberto ;
Mosca, Andrea ;
Panteghini, Mauro .
CLINICA CHIMICA ACTA, 2010, 411 (21-22) :1606-1610
[4]   Limited clinical utility of high-sensitivity plasma C-reactive protein assays [J].
Campbell, B ;
Badrick, T ;
Flatman, R ;
Kanowski, D .
ANNALS OF CLINICAL BIOCHEMISTRY, 2002, 39 :85-88
[5]   Seasonal and Sex Variation of High-Sensitivity C-Reactive Protein in Healthy Adults: A Longitudinal Study [J].
Chiriboga, David E. ;
Ma, Yunsheng ;
Li, Wenjun ;
Stanek, Edward J., III ;
Hebert, James R. ;
Merriam, Philip A. ;
Rawson, Eric S. ;
Ockene, Ira S. .
CLINICAL CHEMISTRY, 2009, 55 (02) :313-321
[6]   The biological variation of C-reactive protein in polycystic ovarian syndrome [J].
Cho, LW ;
Jayagopal, V ;
Kilpatrick, ES ;
Atkin, SL .
CLINICAL CHEMISTRY, 2005, 51 (10) :1905-1907
[7]   BIOLOGICAL VARIATION OF ACUTE-PHASE PROTEINS [J].
CLARK, GH ;
FRASER, CG .
ANNALS OF CLINICAL BIOCHEMISTRY, 1993, 30 :373-376
[8]  
d'Erill GM, 2001, CLIN CHEM, V47, P1498
[9]   Interindividual and intraindividual variability in plasma fibrinogen, TPA antigen, PAI activity, and CRP in healthy, young volunteers and patients with angina pectoris [J].
deMaat, MPM ;
deBart, ACW ;
Hennis, BC ;
Meijer, P ;
Havelaar, AC ;
Mulder, PGH ;
Kluft, C .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1996, 16 (09) :1156-1162
[10]   Need for correct estimates of biological variation: The example of C-reactive protein [J].
Franzini, C .
CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 1998, 36 (02) :131-132