Could MYC induction of mitochondrial biogenesis be linked to ROS production and genomic instability?

被引：45

作者：

Dang, CV ^{[1
]}

Li, F ^{[1
]}

Lee, LA ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

来源：

CELL CYCLE | 2005年 / 4卷 / 11期

关键词：

reactive oxygen; genomic instability; transcription;

D O I：

10.4161/cc.4.11.2121

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

MYC has been linked separately to genomic instability and to reactive oxygen species production, but the connection between these two processes has not been firmly established. Our recent study along with previous reports demonstrate that Myc induces nuclear encoded mitochondrial gene expression and mitochondrial biogenesis, thereby directly associating Myc's transcriptional properties, to the production of mitochondrial ROS and the promotion of genomic oxidative damage and genomic instability.

引用

页码：1465 / 1466

页数：2

共 22 条

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