Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II

被引：323

作者：

Pfeifer, A ^{[1
]}

Aszodi, A ^{[1
]}

Seidler, U ^{[1
]}

Ruth, P ^{[1
]}

Hofmann, F ^{[1
]}

Fassler, R ^{[1
]}

机构：

[1] UNIV TUBINGEN,MED KLIN 1,D-72076 TUBINGEN,GERMANY

来源：

SCIENCE | 1996年 / 274卷 / 5295期

关键词：

D O I：

10.1126/science.274.5295.2082

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cyclic guanosine 3',5'-monophosphate (cGMP)-dependent protein kinases (cGKs) mediate cellular signaling induced by nitric oxide and cGMP. Mice deficient in the type II cGK were resistant to Escherichia coli STa, an enterotoxin that stimulates cGMP accumulation and intestinal fluid secretion. The cGKII-deficient mice also developed dwarfism that was caused by a severe defect in endochondral ossification at the growth plates. These results indicate that cGKII plays a central role in diverse physiological processes.

引用

页码：2082 / 2086

页数：5

共 27 条

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