Isolated polycystic liver disease not linked to polycystic kidney disease 1 and 2

被引:27
作者
Iglesias, DM
Palmitano, JA
Arrizurieta, E
Kornblihtt, AR
Herrera, M
Bernath, V
Martin, RS
机构
[1] Univ Buenos Aires, Inst Invest Med Alfredo Lanari, RA-1427 Buenos Aires, DF, Argentina
[2] Univ Buenos Aires, Fac Ciencias Exactas, Lab Fisiol Mol, Buenos Aires, DF, Argentina
[3] Biol Mol Diagnost SA, Buenos Aires, DF, Argentina
关键词
polycystic liver disease; polycystic kidney disease; genetic linkage; microsatellites;
D O I
10.1023/A:1026623005401
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Autosomal dominant polycystic liver disease occurs commonly in association with autosomal dominant polycystic kidney disease, types 1 and 2. It may also exist as a separate entity, genetically distinct from autosomal dominant polycystic kidney disease types 1 and 2, as has been recently established to exist in a Belgian family. We report here a large Argentinian family of Spanish-Belgian ancestry with autosomal dominant polycystic liver disease, where proximal and distal markers for both polycystic kidney disease 1 and 2 failed to demonstrate genetic linkage. The data support the notion that polycystic liver disease and autosomal dominant polycystic kidney disease may have separate chromosomal loci.
引用
收藏
页码:385 / 388
页数:4
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