Loss of E-cadherin promotes the growth, invasion and drug resistance of colorectal cancer cells and is associated with liver metastasis

被引:68
作者
Chen, Xiaobing [2 ]
Wang, Yongsheng [3 ]
Xia, Hongping [1 ]
Wang, Qiwu [4 ]
Jiang, Xiaochun [1 ]
Lin, Zihong [5 ]
Ma, Yuedong [5 ]
Yang, Yang [5 ]
Hu, Minghua [1 ]
机构
[1] Yijishan Hosp, Dept Surg, Wannan Med Coll, Wuhu 241001, Peoples R China
[2] Zhengzhou Univ, Henan Canc Hosp, Affiliated Canc Hosp, Zhengzhou 450008, Peoples R China
[3] Tongji Univ, Shanghai Pulm Hosp, Shanghai 200433, Peoples R China
[4] Chengdu Mil Gen Hosp, Chengdu 610083, Peoples R China
[5] Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou 510080, Guangdong, Peoples R China
关键词
E-cadherin; Colorectal cancer; Metastasis; Epithelial-to-mesenchymal transition; EPITHELIAL-MESENCHYMAL TRANSITION; BETA-CATENIN; MOLECULAR-MECHANISMS; PROGNOSTIC-SIGNIFICANCE; EXPRESSION; PATHWAY;
D O I
10.1007/s11033-012-1494-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The recent studies indicated that the epithelial cell adhesion molecule E-cadherin is a well-recognized molecule that is important in cell adhesion. To further investigate the molecular basis of this notion, we used small-interfering RNA to inhibit E-cadherin function and found that loss of E-cadherin promoted Colorectal cancer cell growth, invasion and drug resistance through induction of beta-catenin nuclear translocation and epithelial-to-mesenchymal transition. Further analysis of E-cadherin expression with clinicopathologic parameters showed that E-cadherin expression decreased in Colorectal cancer patients who developed liver metastasis (P = 0.043). These findings indicate that E-cadherin loss in tumors contributes to progression and metastatic dissemination. Thus, E-cadherin can act as a central modulator of the cell biological phenotypes and a potential prognostic marker in Colorectal cancer.
引用
收藏
页码:6707 / 6714
页数:8
相关论文
共 30 条
  • [1] Epithelial-mesenchymal transition and colorectal cancer: Gaining insights into tumor progression using LIM 1863 cells
    Bates, Richard C.
    Pursell, Bryan M.
    Mercurio, Arthur M.
    [J]. CELLS TISSUES ORGANS, 2007, 185 (1-3) : 29 - 39
  • [2] MOLECULAR-CLONING AND CHARACTERIZATION OF THE HUMAN E-CADHERIN CDNA
    BUSSEMAKERS, MJG
    VANBOKHOVEN, A
    MEES, SGM
    KEMLER, R
    SCHALKEN, JA
    [J]. MOLECULAR BIOLOGY REPORTS, 1993, 17 (02) : 123 - 128
  • [3] Molecular mechanisms of tumor invasion and metastasis: An integrated view
    Cairns, RA
    Khokha, R
    Hill, RP
    [J]. CURRENT MOLECULAR MEDICINE, 2003, 3 (07) : 659 - 671
  • [4] Dissemination and growth of cancer cells in metastatic sites
    Chambers, AF
    Groom, AC
    MacDonald, IC
    [J]. NATURE REVIEWS CANCER, 2002, 2 (08) : 563 - 572
  • [5] Nuclear E-cadherin immunoexpression - From biology to potential applications in diagnostic pathology
    Chetty, Runjan
    Serra, Stefano
    [J]. ADVANCES IN ANATOMIC PATHOLOGY, 2008, 15 (04) : 234 - 240
  • [6] Nasopharyngeal carcinoma - Review of the molecular mechanisms of tumorigenesis
    Chou, Josephine
    Lin, Yu-Ching
    Kim, Jae
    You, Liang
    Xu, Zhidong
    He, Biao
    Jablons, David M.
    [J]. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2008, 30 (07): : 946 - 963
  • [7] Autoregulation of E-cadherin expression by cadherin-cadherin interactions:: the roles of β-catenin signaling, Slug, and MAPK
    Conacci-Sorrell, M
    Simcha, I
    Ben-Yedidia, T
    Blechman, J
    Savagner, P
    Ben-Ze'ev, A
    [J]. JOURNAL OF CELL BIOLOGY, 2003, 163 (04) : 847 - 857
  • [8] Timeline - The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited
    Fidler, IJ
    [J]. NATURE REVIEWS CANCER, 2003, 3 (06) : 453 - 458
  • [9] Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis
    Grünert, S
    Jechlinger, M
    Beug, H
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2003, 4 (08) : 657 - 665
  • [10] Cancer metastasis:: Building a framework
    Gupta, Gaorav P.
    Massague, Joan
    [J]. CELL, 2006, 127 (04) : 679 - 695