Loss of E-cadherin promotes the growth, invasion and drug resistance of colorectal cancer cells and is associated with liver metastasis
被引:68
作者:
Chen, Xiaobing
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Zhengzhou Univ, Henan Canc Hosp, Affiliated Canc Hosp, Zhengzhou 450008, Peoples R ChinaYijishan Hosp, Dept Surg, Wannan Med Coll, Wuhu 241001, Peoples R China
Chen, Xiaobing
[2
]
Wang, Yongsheng
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机构:
Tongji Univ, Shanghai Pulm Hosp, Shanghai 200433, Peoples R ChinaYijishan Hosp, Dept Surg, Wannan Med Coll, Wuhu 241001, Peoples R China
Wang, Yongsheng
[3
]
Xia, Hongping
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机构:
Yijishan Hosp, Dept Surg, Wannan Med Coll, Wuhu 241001, Peoples R ChinaYijishan Hosp, Dept Surg, Wannan Med Coll, Wuhu 241001, Peoples R China
Xia, Hongping
[1
]
Wang, Qiwu
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机构:
Chengdu Mil Gen Hosp, Chengdu 610083, Peoples R ChinaYijishan Hosp, Dept Surg, Wannan Med Coll, Wuhu 241001, Peoples R China
Wang, Qiwu
[4
]
Jiang, Xiaochun
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Yijishan Hosp, Dept Surg, Wannan Med Coll, Wuhu 241001, Peoples R ChinaYijishan Hosp, Dept Surg, Wannan Med Coll, Wuhu 241001, Peoples R China
Jiang, Xiaochun
[1
]
Lin, Zihong
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机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou 510080, Guangdong, Peoples R ChinaYijishan Hosp, Dept Surg, Wannan Med Coll, Wuhu 241001, Peoples R China
Lin, Zihong
[5
]
Ma, Yuedong
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h-index: 0
机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou 510080, Guangdong, Peoples R ChinaYijishan Hosp, Dept Surg, Wannan Med Coll, Wuhu 241001, Peoples R China
Ma, Yuedong
[5
]
Yang, Yang
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h-index: 0
机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou 510080, Guangdong, Peoples R ChinaYijishan Hosp, Dept Surg, Wannan Med Coll, Wuhu 241001, Peoples R China
Yang, Yang
[5
]
Hu, Minghua
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Yijishan Hosp, Dept Surg, Wannan Med Coll, Wuhu 241001, Peoples R ChinaYijishan Hosp, Dept Surg, Wannan Med Coll, Wuhu 241001, Peoples R China
Hu, Minghua
[1
]
机构:
[1] Yijishan Hosp, Dept Surg, Wannan Med Coll, Wuhu 241001, Peoples R China
[2] Zhengzhou Univ, Henan Canc Hosp, Affiliated Canc Hosp, Zhengzhou 450008, Peoples R China
[3] Tongji Univ, Shanghai Pulm Hosp, Shanghai 200433, Peoples R China
[4] Chengdu Mil Gen Hosp, Chengdu 610083, Peoples R China
[5] Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou 510080, Guangdong, Peoples R China
The recent studies indicated that the epithelial cell adhesion molecule E-cadherin is a well-recognized molecule that is important in cell adhesion. To further investigate the molecular basis of this notion, we used small-interfering RNA to inhibit E-cadherin function and found that loss of E-cadherin promoted Colorectal cancer cell growth, invasion and drug resistance through induction of beta-catenin nuclear translocation and epithelial-to-mesenchymal transition. Further analysis of E-cadherin expression with clinicopathologic parameters showed that E-cadherin expression decreased in Colorectal cancer patients who developed liver metastasis (P = 0.043). These findings indicate that E-cadherin loss in tumors contributes to progression and metastatic dissemination. Thus, E-cadherin can act as a central modulator of the cell biological phenotypes and a potential prognostic marker in Colorectal cancer.
机构:
Univ Calif San Francisco, Ctr Comprehens Canc, Thorac Oncol Lab, Dept Surg, San Francisco, CA 94115 USAUniv Calif San Francisco, Ctr Comprehens Canc, Thorac Oncol Lab, Dept Surg, San Francisco, CA 94115 USA
Chou, Josephine
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Lin, Yu-Ching
Kim, Jae
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Univ Calif San Francisco, Ctr Comprehens Canc, Thorac Oncol Lab, Dept Surg, San Francisco, CA 94115 USAUniv Calif San Francisco, Ctr Comprehens Canc, Thorac Oncol Lab, Dept Surg, San Francisco, CA 94115 USA
Kim, Jae
You, Liang
论文数: 0引用数: 0
h-index: 0
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Univ Calif San Francisco, Ctr Comprehens Canc, Thorac Oncol Lab, Dept Surg, San Francisco, CA 94115 USAUniv Calif San Francisco, Ctr Comprehens Canc, Thorac Oncol Lab, Dept Surg, San Francisco, CA 94115 USA
You, Liang
Xu, Zhidong
论文数: 0引用数: 0
h-index: 0
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Univ Calif San Francisco, Ctr Comprehens Canc, Thorac Oncol Lab, Dept Surg, San Francisco, CA 94115 USAUniv Calif San Francisco, Ctr Comprehens Canc, Thorac Oncol Lab, Dept Surg, San Francisco, CA 94115 USA
Xu, Zhidong
He, Biao
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Univ Calif San Francisco, Ctr Comprehens Canc, Thorac Oncol Lab, Dept Surg, San Francisco, CA 94115 USAUniv Calif San Francisco, Ctr Comprehens Canc, Thorac Oncol Lab, Dept Surg, San Francisco, CA 94115 USA
He, Biao
Jablons, David M.
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Univ Calif San Francisco, Ctr Comprehens Canc, Thorac Oncol Lab, Dept Surg, San Francisco, CA 94115 USAUniv Calif San Francisco, Ctr Comprehens Canc, Thorac Oncol Lab, Dept Surg, San Francisco, CA 94115 USA
Jablons, David M.
[J].
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK,
2008,
30
(07):
: 946
-
963
机构:
Mem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, New York, NY 10021 USA
Gupta, Gaorav P.
Massague, Joan
论文数: 0引用数: 0
h-index: 0
机构:Mem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, New York, NY 10021 USA
机构:
Univ Calif San Francisco, Ctr Comprehens Canc, Thorac Oncol Lab, Dept Surg, San Francisco, CA 94115 USAUniv Calif San Francisco, Ctr Comprehens Canc, Thorac Oncol Lab, Dept Surg, San Francisco, CA 94115 USA
Chou, Josephine
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机构:
Lin, Yu-Ching
Kim, Jae
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Ctr Comprehens Canc, Thorac Oncol Lab, Dept Surg, San Francisco, CA 94115 USAUniv Calif San Francisco, Ctr Comprehens Canc, Thorac Oncol Lab, Dept Surg, San Francisco, CA 94115 USA
Kim, Jae
You, Liang
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Ctr Comprehens Canc, Thorac Oncol Lab, Dept Surg, San Francisco, CA 94115 USAUniv Calif San Francisco, Ctr Comprehens Canc, Thorac Oncol Lab, Dept Surg, San Francisco, CA 94115 USA
You, Liang
Xu, Zhidong
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Ctr Comprehens Canc, Thorac Oncol Lab, Dept Surg, San Francisco, CA 94115 USAUniv Calif San Francisco, Ctr Comprehens Canc, Thorac Oncol Lab, Dept Surg, San Francisco, CA 94115 USA
Xu, Zhidong
He, Biao
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Ctr Comprehens Canc, Thorac Oncol Lab, Dept Surg, San Francisco, CA 94115 USAUniv Calif San Francisco, Ctr Comprehens Canc, Thorac Oncol Lab, Dept Surg, San Francisco, CA 94115 USA
He, Biao
Jablons, David M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Ctr Comprehens Canc, Thorac Oncol Lab, Dept Surg, San Francisco, CA 94115 USAUniv Calif San Francisco, Ctr Comprehens Canc, Thorac Oncol Lab, Dept Surg, San Francisco, CA 94115 USA
Jablons, David M.
[J].
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK,
2008,
30
(07):
: 946
-
963
机构:
Mem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, New York, NY 10021 USA
Gupta, Gaorav P.
Massague, Joan
论文数: 0引用数: 0
h-index: 0
机构:Mem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, New York, NY 10021 USA