Catalase-peroxidase activity has no influence on virulence in a murine model of tuberculosis

被引：15

作者：

Cardona, PJ

Gordillo, S

Amat, I

Díaz, J

Lonca, J

Vilaplana, C

Pallarés, A

Llatjós, R

Ariza, A

Ausina, V

机构：

[1] Univ Autonoma Barcelona, Unitat TB Expt, Dept Microbiol, Hosp Germans Trias & Pujol, Badalona 08916, Catalonia, Spain

[2] Univ Autonoma Barcelona, Hosp Germans Trias & Pujol, Dept Pathol, Badalona 08916, Catalonia, Spain

来源：

TUBERCULOSIS | 2003年 / 83卷 / 06期

关键词：

tuberculosis; murine model; virulence; catalase-peroxidase; isoniazid;

D O I：

10.1016/S1472-9792(03)00056-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The capacity to generate a chronic and persistent infection in the experimental murine model of tuberculosis induced aerogenically by a low-dose inoculum was determined in eight isoniazid-resistant clinical strains of Mycobacterium tuberculosis showing different catalase-peroxidase (C-P) activities. Determination of bacillary concentration in lung and spleen and the percentage of pulmonary parenchyma occupied by granulomas were monitored. Data showed no relation between the lack of C-P activity and the ability to develop a persistent infection, highlighting the potential of C-P negative strains to spread through the community. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：351 / 359

页数：9

共 42 条

[1] Mechanism of isoniazid uptake in Mycobacterium tuberculosis [J].

Bardou, F ;

Raynaud, C ;

Ramos, C ;

Lanéelle, MA ;

Lanéelle, G .

MICROBIOLOGY-UK, 1998, 144 :2539-2544

[2] NATIONWIDE SURVEY OF DRUG-RESISTANT TUBERCULOSIS IN THE UNITED-STATES [J].

BLOCH, AB ;

CAUTHEN, GM ;

ONORATO, IM ;

DANSBURY, KG ;

KELLY, GD ;

DRIVER, CR ;

SNIDER, DE .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1994, 271 (09) :665-671

[3]

CANETTI G, 1976, TECHNIQUES INDICATIO, P77

[4] Evolution of granulomas in lungs of mice infected aerogenically with Mycobacterium tuberculosis [J].

Cardona, PJ ;

Llatjós, R ;

Gordillo, S ;

Díaz, J ;

Ojanguren, I ;

Ariza, A ;

Ausina, V .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2000, 52 (02) :156-163

[5]

Cardona PJ, 1999, SCAND J IMMUNOL, V49, P362

[6] MICROBIAL GLYCOLIPIDS - POSSIBLE VIRULENCE FACTORS THAT SCAVENGE OXYGEN RADICALS [J].

CHAN, J ;

FUJIWARA, T ;

BRENNAN, P ;

MCNEIL, M ;

TURCO, SJ ;

SIBILLE, JC ;

SNAPPER, M ;

AISEN, P ;

BLOOM, BR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (07) :2453-2457

[7] LIPOARABINOMANNAN, A POSSIBLE VIRULENCE FACTOR INVOLVED IN PERSISTENCE OF MYCOBACTERIUM-TUBERCULOSIS WITHIN MACROPHAGES [J].

CHAN, J ;

FAN, X ;

HUNTER, SW ;

BRENNAN, PJ ;

BLOOM, BR .

INFECTION AND IMMUNITY, 1991, 59 (05) :1755-1761

[8] Application of molecular methods for detection and transmission analysis of Mycobacterium tuberculosis drug resistance in patients attending a reference hospital in Italy [J].

Cingolani, A ;

Antinori, A ;

Sanguinetti, M ;

Gillini, L ;

De Luca, A ;

Posteraro, B ;

Ardito, F ;

Fadda, G ;

Ortona, L .

JOURNAL OF INFECTIOUS DISEASES, 1999, 179 (04) :1025-1029

[9]

COHN ML, 1954, AM REV TUBERC PULM, V70, P641

[10] Transient loss of resistance to pulmonary tuberculosis in p47phox-/- mice [J].

Cooper, AM ;

Segal, BH ;

Frank, AA ;

Holland, SM ;

Orme, IM .

INFECTION AND IMMUNITY, 2000, 68 (03) :1231-1234

← 1 2 3 4 5 →