A mid-life crisis for aging theory

被引:13
作者
Garber, Ken
机构
关键词
D O I
10.1038/nbt0408-371
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
From yeast to mice, limiting food intake slows aging and extends lifespan. Activators of the sirtuins, enzymes famously linked to this process, promise a wealth of new drugs, but the sirtuin hypothesis is now coming under fire. The lifespan was dramatically extended in yeast bearing an extra copy of a sirtuin, the conserved enzyme class. Sirtuins have been shown to extend lifespan in many other organisms, but a schism in the field has erupted over the role that these proteins play in the aging process. Sirtuins are responsible for the health, and longevity, enhancing effects of calorie restriction, a treatment that extends healthy lifespan 40% or more in many organisms, including mice and rats. Drugs such as resveratrol and the antidiabetic drug, SRT501 could treat diseases related to aging.
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页码:371 / 374
页数:4
相关论文
共 22 条
  • [1] Altered sirtuin expression is associated with node-positive breast cancer
    Ashraf, N.
    Zino, S.
    MacIntyre, A.
    Kingsmore, D.
    Payne, A. P.
    George, W. D.
    Shiels, P. G.
    [J]. BRITISH JOURNAL OF CANCER, 2006, 95 (08) : 1056 - 1061
  • [2] Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans
    Bass, Timothy M.
    Weinkove, David
    Houthoofd, Koen
    Gems, David
    Partridge, Linda
    [J]. MECHANISMS OF AGEING AND DEVELOPMENT, 2007, 128 (10) : 546 - 552
  • [3] Resveratrol improves health and survival of mice on a high-calorie diet
    Baur, Joseph A.
    Pearson, Kevin J.
    Price, Nathan L.
    Jamieson, Hamish A.
    Lerin, Carles
    Kalra, Avash
    Prabhu, Vinayakumar V.
    Allard, Joanne S.
    Lopez-Lluch, Guillermo
    Lewis, Kaitlyn
    Pistell, Paul J.
    Poosala, Suresh
    Becker, Kevin G.
    Boss, Olivier
    Gwinn, Dana
    Wang, Mingyi
    Ramaswamy, Sharan
    Fishbein, Kenneth W.
    Spencer, Richard G.
    Lakatta, Edward G.
    Le Couteur, David
    Shaw, Reuben J.
    Navas, Placido
    Puigserver, Pere
    Ingram, Donald K.
    de Cabo, Rafael
    Sinclair, David A.
    [J]. NATURE, 2006, 444 (7117) : 337 - 342
  • [4] SIRT1 transgenic mice show phenotypes resembling calorie restriction
    Bordone, Laura
    Cohen, Dena
    Robinson, Ashley
    Motta, Maria Carla
    van Veen, Ed
    Czopik, Agnieszka
    Steele, Andrew D.
    Crowe, Hayley
    Marmor, Stephen
    Luo, Jianyuan
    Gu, Wei
    Guarente, Leonard
    [J]. AGING CELL, 2007, 6 (06) : 759 - 767
  • [5] Mechanism of human SIRT1 activation by resveratrol
    Borra, MT
    Smith, BC
    Denu, JM
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (17) : 17187 - 17195
  • [6] Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues
    de Nigris, F
    Cerutti, J
    Morelli, C
    Califano, D
    Chiariotti, L
    Viglietto, G
    Santelli, G
    Fusco, A
    [J]. BRITISH JOURNAL OF CANCER, 2002, 86 (06) : 917 - 923
  • [7] Sir2 blocks extreme life-span extension
    Fabrizio, P
    Gattazzo, C
    Battistella, L
    Wei, M
    Cheng, C
    McGrew, K
    Longo, VD
    [J]. CELL, 2005, 123 (04) : 655 - 667
  • [8] Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
    Howitz, KT
    Bitterman, KJ
    Cohen, HY
    Lamming, DW
    Lavu, S
    Wood, JG
    Zipkin, RE
    Chung, P
    Kisielewski, A
    Zhang, LL
    Scherer, B
    Sinclair, DA
    [J]. NATURE, 2003, 425 (6954) : 191 - 196
  • [9] SIRT1 is significantly elevated in mouse and human prostate cancer
    Huffman, Derek M.
    Grizzle, William E.
    Bamman, Marcas M.
    Kim, Jeong-su
    Eltoum, Isam A.
    Elgavish, Ada
    Nagy, Tim R.
    [J]. CANCER RESEARCH, 2007, 67 (14) : 6612 - 6618
  • [10] The molecular biology of mammalian SIRT proteins - SIRT2 in cell cycle regulation
    Inoue, Toshiaki
    Hiratsuka, Masaharu
    Osaki, Mitsuhiko
    Oshimura, Mitsuo
    [J]. CELL CYCLE, 2007, 6 (09) : 1011 - 1018