Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites

被引：32

作者：

Glenn, MR

Chang, SY

Hucke, O

Verlinde, CLMJ

Rivas, K

Hornéy, C

Yokoyama, K

Buckner, FS

Pendyala, PR

Chakrabarti, D

Gelb, M

Van Voorhis, WC

Sebti, SM

Hamilton, AD

机构：

[1] Yale Univ, Dept Chem, New Haven, CT 06511 USA

[2] Univ Washington, Dept Biochem, Seattle, WA 98195 USA

[3] Univ Washington, Dept Med, Seattle, WA 98195 USA

[4] Univ Washington, Dept Chem & Biochem, Seattle, WA 98195 USA

[5] Univ S Florida, Drug Discovery Program, H Lee Moffitt Canc Ctr, Tampa, FL 33612 USA

[6] Univ S Florida, Inst Res, Dept Oncol, Tampa, FL 33612 USA

[7] Univ S Florida, Dept Biochem & Mol Biol, Tampa, FL 33612 USA

[8] Univ Cent Florida, Dept Mol Biol & Microbiol, Orlando, FL 32826 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 31期

关键词：

drug design; enzymes; inhibitors; malaria; medicinal chemistry;

D O I：

10.1002/anie.200500674

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Antimalarial compounds: Structurally simple acyclic inhibitors of protein farnesyltransferase (active-site model shown) from the malaria parasite Plasmodium falciparum may allow third world countries access to an effective and inexpensive antimalarial therapy to counter the estimated half billion infections that occur annually. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

收藏

页码：4903 / 4906

页数：4

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