Molecular modelling of 2′-OH mediated hydrogen bonding in ribonucleos(t)ides by NMR constrained AM1 and MMX calculations

被引：3

作者：

Acharya, P ^{[1
]}

Velikian, I ^{[1
]}

Acharya, S ^{[1
]}

Chattopadhyaya, J ^{[1
]}

机构：

[1] Univ Uppsala, Ctr Biomed, Dept Bioorgan Chem, S-75123 Uppsala, Sweden

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2001年 / 20卷 / 4-7期

关键词：

D O I：

10.1081/NCN-100002521

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The intra- and intermolecular hydrogen bonding (DeltaG(298K)degrees approximate to 2 kcal mol(-1)) of 2'-OH in nucleos(t)ides has been reported by the temperature- and concentration-dependent NMR study in conjunction with dihedral dependence of the NMR derived both endo ((3)J(H,H))- and exocyclic ((3)J(H,OH)) coupling constants, nOe contacts and lineshape analyses of hydroxyl protons for EtpA (1), 3'-dA (2), rA (3), 2'-dA (4) [Fig. 1] in DMSO-d(6) at 500 MHz.

引用

页码：1211 / 1217

页数：7

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