Studies with enaminones:: Synthesis of new coumarin-3-yl azoles, coumarin-3-yl azines, coumarin-3-yl azoloazines, coumarin-3-yl pyrone and coumarin-2-yl benzo[b]furans

被引:79
作者
El-Taweel, FMAA [1 ]
Elnagdi, MH
机构
[1] Univ Mansoura, Fac Sci, Dept Chem, Mansoura, Egypt
[2] Cairo Univ, Fac Sci, Dept Chem, Giza, Egypt
关键词
D O I
10.1002/jhet.5570380428
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
3-Acetylcoumarine was condensed with dimethylformamide dimethylacetal (DMFDMA) to yield the enaminone, which reacts readily with hydroxylamine and with hydrazines to yield coumarin-3-ylisoxazoles and coumarin-3-ylpyrazoles respectively. Reaction of the enaminone with benzamidine hydrochloride and 3-amino-1,2,4-1H-triazole affords the pyrimidine and triazolo[3,4-b]pyrimidine. The enaminone reacts with hippuric acid and with the dithiocarboxylic acid to yield pyranones. The reaction of the enaminone with 3-amino-1H-1,2,4-triazole gives the triazolo[3,4-b]pyrimidine. The enaminone underwent self dimerization on reflux in acetic acid ammonium acetate to yield the coumarinyl pyridines and reacted with ketone under the same conditions to yield the pyridine. The reaction of the enaminone with 1,4-benzoquinone and 1,4-naphthoquinone gives benzofuryl coumarine derivatives.
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收藏
页码:981 / 984
页数:4
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