Alterations of sucrose preference after Roux-en-Y gastric bypass

被引：143

作者：

Bueter, M. ^{[1
,2
]}

Miras, A. D. ^{[1
]}

Chichger, H. ^{[3
,4
]}

Fenske, W. ^{[1
]}

Ghatei, M. A. ^{[1
]}

Bloom, S. R. ^{[1
]}

Unwin, R. J. ^{[3
,4
]}

Lutz, T. A. ^{[5
,6
]}

Spector, A. C. ^{[7
,8
]}

le Roux, C. W. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Imperial Weight Ctr, Dept Invest Med, London W6 8RF, England

[2] Univ Zurich Hosp, Dept Surg, Div Visceral & Transplantat Surg, CH-8091 Zurich, Switzerland

[3] UCL, UCL Ctr Nephrol, London, England

[4] UCL, Dept Neurosci Physiol & Pharmacol, London, England

[5] Univ Zurich, Inst Vet Physiol, Vetsuisse Fac, Zurich, Switzerland

[6] Univ Zurich, Vetsuisse Fac, Zurich Ctr Integrat Human Physiol, Zurich, Switzerland

[7] Florida State, Dept Psychol, Tallahassee, FL USA

[8] Florida State Univ, Program Neurosci, Tallahassee, FL 32306 USA

来源：

PHYSIOLOGY & BEHAVIOR | 2011年 / 104卷 / 05期

基金：

新加坡国家研究基金会; 英国生物技术与生命科学研究理事会;

关键词：

Gastric bypass; Gut hormones; Preference; Detection; Hedonic rating; Neophobia; GLUCAGON-LIKE PEPTIDE-1; VERTICAL BANDED GASTROPLASTY; SWEET TASTE SENSITIVITY; FOOD-INTAKE; WEIGHT-LOSS; REGULATE SECRETION; OBESE SUBJECTS; DIETARY-INTAKE; GUT HORMONES; RATS;

D O I：

10.1016/j.physbeh.2011.07.025

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Roux-en-Y gastric bypass (gastric bypass) patients reportedly have changes in perception and consumption of sweet-tasting foods. This study aimed to further investigate alterations in sweet food intake in rats and sucrose detection in humans after gastric bypass. Wistar rats were randomized to gastric bypass or sham-operations and preference for sucrose (sweet), sodium chloride (salty), citric acid (sour) and quinine hydrochloride (bitter) was assessed with standard two-bottle intake tests (vs. water). Intestinal T1R2 and T1R3 expression and plasma levels of glucagon-like-peptide 1 (GLP-1) and peptide YY (PYY) were measured. Furthermore, obese patients and normal weight controls were tested for sucrose taste detection thresholds pre- and postoperatively. Visual analogue scales measuring hedonic perception were used to determine the sucrose concentration considered by patients and controls as "just about right" pre- and postoperatively. Gastric bypass reduced the sucrose intake relative to water in rats (p<0.001). Preoperative sucrose exposure reduced this effect. Preference or aversion for compounds representative of other taste qualities in naive rats remained unaffected. Intestinal T1R2 and T1R3 expression was significantly decreased in the alimentary limb while plasma levels of GLP-1 and PYY were elevated after bypass in rats (p = 0.01). Bypass patients showed increased taste sensitivity to low sucrose concentrations compared with controls (p<0.05), but both groups considered the same sucrose concentration as "just about right" postoperatively. In conclusion, gastric bypass reduces sucrose intake relative to water in sucrose-naive rats, but preoperative sucrose experience attenuates this effect. Changes in sucrose taste detection do not predict hedonic taste ratings of sucrose in bypass patients which remain unchanged. Thus, factors other than the unconditional affective value of the taste may also play a role in determining food preferences after gastric bypass. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：709 / 721

页数：13

共 61 条

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