Solvent-free condensation of arylacetonitrile with aldehydes

被引：34

作者：

Guillot, W

Loupy, A

Meddour, A

Pellet, M

Petit, A

机构：

[1] Univ Paris 11, CNRS, UMR 8615, Lab React Select Supports, F-91405 Orsay, France

[2] Univ Paris 11, ICMMO, F-91405 Orsay, France

[3] Univ Paris 11, CNRS 8074, Lab RMN Milieu Oriente, F-91405 Orsay, France

[4] Univ Paris 11, CNRS, UMR 8615, Lab Carbocycles, F-91405 Orsay, France

来源：

TETRAHEDRON | 2005年 / 61卷 / 42期

关键词：

solvent-free condensation; microwave irradiation; phase transfer catalysis; X-ray crystallography;

D O I：

10.1016/j.tet.2005.07.040

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The condensation of a series of arylacetonitriles with aldehydes can be carried out by mixing equivalent amounts of reagents with neat powdered KOH at room temperature for 3-60 min depending on the aldehyde steric hindrance. At higher temperature (110 degrees C), yields were generally higher and purity increased within very short reaction times (1-5 min). With pentamethylphenylacetonitrile, a phase transfer agent was necessary to give a satisfactory yield. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：10129 / 10137

页数：9

共 25 条

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