c-Jun activating binding protein 1 binds to the IgA receptor and modulates protein levels of FcαRI and FcR γ-chain

被引：7

作者：

Bakema, Jantine E. ^{[1
,2
]}

Hiemstra, Ida H. ^{[1
,2
]}

Bakker, Johanna ^{[1
]}

de Haij, Simone ^{[1
]}

Kok, Yvonne ^{[1
]}

Adema, Gosse ^{[3
]}

van Egmond, Marjolein ^{[2
]}

Coffer, Paul J. ^{[4
]}

van de Winkel, Jan G. J. ^{[1
,5
]}

Leusen, Jeanette H. W. ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Immunotherapy Lab, Dept Immunol, Utrecht, Netherlands

[2] Vrije Univ Amsterdam Med Ctr, Dept Mol Cell Biol & Immunol, Amsterdam, Netherlands

[3] Ctr Mol Life Sci & Med Oncol, Dept Tumor Immunol, Nijmegen, Netherlands

[4] Univ Med Ctr Utrecht, Mol Immunol Lab, Dept Immunol, Utrecht, Netherlands

[5] Genmab, Utrecht, Netherlands

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2010年 / 40卷 / 07期

关键词：

c-Jun activating binding protein 1; Fc alpha RI; Protein expression; COP9; SIGNALOSOME; CD89; DEPENDS; DEGRADATION; JAB1; ASSOCIATION; COACTIVATOR; P27(KIP1); INTERACTS; COMPLEX; KINASE;

D O I：

10.1002/eji.200939985

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The receptor for IgA, Fc alpha RI or CD89, is expressed on myeloid cells and can trigger phagocytosis, tumor cell lysis, and release of inflammatory mediators. These functions critically depend on the associated FcR gamma-chain; however, some biological functions, like receptor internalization, are solely mediated by Fc alpha RI alpha-chain. Little is known as to how Fc alpha RI regulates these processes and the Fc alpha RI intracellular domain does not contain recognized signalling motifs. We searched for associating proteins and identified c-Jun activating binding protein 1 (JAB1) as a binding partner specifically for Fc alpha RI. We found increased Fc alpha RI surface expression after ectopic expression of JAB1 as well as diminished protein levels of total FcR gamma-chain levels after JAB1 knock-down. These data functionally link JAB1 with controlling protein expression levels of Fc alpha RI-FcR gamma-chain protein complex.

引用

页码：2035 / 2040

页数：6

共 23 条

[1] Jab1 interacts directly with HIF-1α and regulates its stability [J].

Bae, MK ;

Ahn, MY ;

Jeong, JW ;

Bae, MH ;

Lee, YM ;

Bae, SK ;

Park, JW ;

Kim, KR ;

Kim, KW .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (01) :9-12

[2] Inside-out regulation of FcαRI (CD89) depends on PP2A [J].

Bakema, Jantine E. ;

Bakker, Annie ;

de Haij, Simone ;

Honing, Henk ;

Bracke, Madelon ;

Koenderman, Leo ;

Vidarsson, Gestur ;

van de Winkel, Jan G. J. ;

Leusen, Jeanette H. W. .

JOURNAL OF IMMUNOLOGY, 2008, 181 (06) :4080-4088

[3] Signaling through mutants of the IgA receptor CD89 and consequences for Fc receptor γ-chain interaction [J].

Bakema, Jantine E. ;

de Haij, Simone ;

den Hartog-Jager, Constance F. ;

Bakker, Johanna ;

Vidarsson, Gestur ;

van Egmond, Marjolein ;

de Winkel, Jan G. J. van ;

Leusen, Jeanette H. W. .

JOURNAL OF IMMUNOLOGY, 2006, 176 (06) :3603-3610

[4] Direct interaction between FcγR1 (CD64) and periplakin controls receptor endocytosis and ligand binding capacity [J].

Beekman, JM ;

Bakema, JE ;

van de Winkel, JGJ ;

Leusen, JHW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (28) :10392-10397

[5] Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity [J].

Bianchi, E ;

Denti, S ;

Granata, A ;

Bossi, G ;

Geginat, J ;

Villa, A ;

Rogge, L ;

Pardi, R .

NATURE, 2000, 404 (6778) :617-+

[6] Delineation of the region in the glycoprotein VI tail required for association with the Fc receptor γ-chain [J].

Bori-Sanz, T ;

Inoue, KS ;

Berndt, MC ;

Watson, SP ;

Tulasne, D .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (38) :35914-35922

[7] Cytokine-induced inside-out activation of FcαR (CD89) is mediated by a single serine residue (S263) in the intracellular domain of the receptor [J].

Bracke, M ;

Lammers, JWJ ;

Coffer, PJ ;

Koenderman, L .

BLOOD, 2001, 97 (11) :3478-3483

[8] A new group of conserved coactivators that increase the specificity of AP-1 transcription factors [J].

Claret, FX ;

Hibi, M ;

Dhut, S ;

Toda, T ;

Karin, M .

NATURE, 1996, 383 (6599) :453-457

[9] Fc receptor biology [J].

Daeron, M .

ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 :203-234

[10] NF-κB mediated IL-6 production by renal epithelial cells is regulated by C-Jun NH2-terminal kinase [J].

de Haij, S ;

Bakker, AC ;

van der Geest, RN ;

Haegeman, G ;

Vanden Berghe, W ;

Aarbiou, J ;

Daha, MR ;

van Kooten, C .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2005, 16 (06) :1603-1611

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