Defining a Standard Set of Patient-centered Outcomes for Men with Localized Prostate Cancer

被引：194

作者：

Martin, Neil E. ^{[1
,2
]}

Massey, Laura ^{[1
]}

Stowell, Caleb ^{[1
]}

Bangma, Chris ^{[3
]}

Briganti, Alberto ^{[4
]}

Bill-Axelson, Anna ^{[5
,6
]}

Blute, Michael ^{[7
]}

Catto, James ^{[8
,9
]}

Chen, Ronald C. ^{[10
]}

D'Amico, Anthony V. ^{[2
]}

Feick, Guenter ^{[11
]}

Fitzpatrick, John M. ^{[12
]}

Frank, Steven J. ^{[13
]}

Froehner, Michael ^{[14
]}

Frydenberg, Mark ^{[15
]}

Glaser, Adam ^{[16
]}

Graefen, Markus ^{[17
]}

Hamstra, Daniel ^{[18
]}

Kibel, Adam ^{[19
]}

Mendenhall, Nancy ^{[20
]}

Moretti, Kim ^{[21
]}

Ramon, Jacob ^{[22
]}

Roos, Ian ^{[23
]}

Sandler, Howard ^{[24
]}

Sullivan, Francis J. ^{[25
]}

Swanson, David ^{[26
]}

Tewari, Ashutosh ^{[27
]}

Vickers, Andrew ^{[28
]}

Wiegel, Thomas ^{[29
]}

Huland, Hartwig ^{[17
]}

机构：

[1] Int Consortium Hlth Outcomes Measurement, Cambridge, MA USA

[2] Harvard Univ, Sch Med, Dana Farber Brigham & Womens Canc Ctr, Dept Radiat Oncol, Boston, MA USA

[3] Erasmus MC, Dept Urol, Rotterdam, Netherlands

[4] Vita Salute San Raffaele Univ Hosp, Dept Urol, Prostate Canc Res Programme, Urol Res Inst, Milan, Italy

[5] Univ Uppsala Hosp, Dept Surg Sci, Dept Urol, Uppsala, Sweden

[6] Natl Prostate Canc Register Sweden, Uppsala, Sweden

[7] Harvard Univ, Dept Urol, Massachusetts Gen Hosp, Sch Med, Boston, MA USA

[8] Univ Sheffield, Acad Urol Unit, Sheffield, S Yorkshire, England

[9] Univ Sheffield, Sch Med, Sheffield Canc Res Ctr, Acad Unit Mol Oncol,CR UK YCR, Sheffield, S Yorkshire, England

[10] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[11] Bundesverband Prostatakrebs Selbsthilfe, Pohlheim, Germany

[12] Irish Canc Soc, Dublin, Ireland

[13] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA

[14] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Urol, D-01062 Dresden, Germany

[15] Monash Univ, Dept Surg, Clayton, Vic 3800, Australia

[16] Leeds Teaching Hosp NHS Trust, Leeds, W Yorkshire, England

[17] Univ Med Ctr Hamburg Eppendorf, Martini Klin, Hamburg, Germany

[18] Univ Michigan Hlth Syst, Dept Radiat Oncol, Ann Arbor, MI USA

[19] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA

[20] Univ Florida, Proton Therapy Inst, Jacksonville, FL USA

[21] Repatriat Gen Hosp, South Australian Prostate Canc Clin Outcomes Coll, Daw Pk, SA, Australia

[22] Chaim Sheba Med Ctr, Dept Urol & Urooncol, IL-52621 Tel Hashomer, Israel

[23] Canc Voices Australia, Melbourne, Vic, Australia

[24] Cedars Sinai Med Ctr, Dept Radiat Oncol, Los Angeles, CA 90048 USA

[25] NUI Galway, Prostate Canc Inst, Galway, Ireland

[26] Univ Texas MD Anderson Canc Ctr, Dept Urol, Houston, TX 77030 USA

[27] Mt Sinai Hosp, Icahn Sch Med, Dept Urol, New York, NY 10029 USA

[28] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA

[29] Univ Hosp Ulm, Dept Radiat Oncol, Ulm, Germany

来源：

EUROPEAN UROLOGY | 2015年 / 67卷 / 03期

关键词：

Outcome measurement; Patient-reported; QUALITY-OF-LIFE; RADICAL PROSTATECTOMY; FUNCTIONAL OUTCOMES; REPORTED OUTCOMES; VALIDATION; SURVIVORS; QUESTIONNAIRE; BRACHYTHERAPY; COMORBIDITY; MORBIDITY;

D O I：

10.1016/j.eururo.2014.08.075

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Value-based health care has been proposed as a unifying force to drive improved outcomes and cost containment. Objective: To develop a standard set of multidimensional patient-centered health outcomes for tracking, comparing, and improving localized prostate cancer (PCa) treatment value. Design, setting, and participants: We convened an international working group of patients, registry experts, urologists, and radiation oncologists to review existing data and practices. Outcome measurements and statistical analysis: The group defined a recommended standard set representing who should be tracked, what should be measured and at what time points, and what data are necessary to make meaningful comparisons. Using a modified Delphi method over a series of teleconferences, the group reached consensus for the Standard Set. Results and limitations: We recommend that the Standard Set apply to men with newly diagnosed localized PCa treated with active surveillance, surgery, radiation, or other methods. The Standard Set includes acute toxicities occurring within 6 mo of treatment as well as patient-reported outcomes tracked regularly out to 10 yr. Patient-reported domains of urinary incontinence and irritation, bowel symptoms, sexual symptoms, and hormonal symptoms are included, and the recommended measurement tool is the Expanded Prostate Cancer Index Composite Short Form. Disease control outcomes include overall, cause-specific, metastasis-free, and biochemical relapse-free survival. Baseline clinical, pathologic, and comorbidity information is included to improve the interpretability of comparisons. Conclusions: We have defined a simple, easily implemented set of outcomes that we believe should be measured in all men with localized PCa as a crucial first step in improving the value of care. Patient summary: Measuring, reporting, and comparing identical outcomes across treatments and treatment centers will provide patients and providers with information to make informed treatment decisions. We defined a set of outcomes that we recommend being tracked for every man being treated for localized prostate cancer. (C) 2014 European Association of Urology. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license

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页码：460 / 467

页数：8

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