Mechanisms facilitating weight loss and resolution of type 2 diabetes following bariatric surgery

被引：96

作者：

Karra, Efthimia ^{[1
]}

Yousseif, Ahmed ^{[1
]}

Batterham, Rachel L. ^{[1
]}

机构：

[1] UCL, Dept Med, Obes Res Ctr, London WC1E 6JJ, England

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2010年 / 21卷 / 06期

关键词：

Y GASTRIC BYPASS; GLUCAGON-LIKE PEPTIDE-1; PLASMA GHRELIN LEVELS; VERTICAL BANDED GASTROPLASTY; JEJUNOILEAL BYPASS; GUT HORMONE; SLEEVE GASTRECTOMY; BODY-WEIGHT; FOOD-INTAKE; BILIOPANCREATIC DIVERSION;

D O I：

10.1016/j.tem.2010.01.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Bariatric surgery is the most effective treatment modality for obesity, resulting in durable weight loss and amelioration of obesity-associated comorbidities, particularly type 2 diabetes mellitus (T2DM). Moreover, the metabolic benefits of bariatric surgery occur independently of weight loss. There is increasing evidence that surgically induced alterations in circulating gut hormones mediate these beneficial effects of bariatric surgery. Here, we summarise current knowledge on the effects of different bariatric procedures on circulating gut hormone levels. We also discuss the theories that have been put forward to explain the weight loss and T2DM resolution following bariatric surgery. Understanding the mechanisms mediating these beneficial outcomes of bariatric surgery could result in new nonsurgical treatment strategies for obesity and T2DM.

引用

页码：337 / 344

页数：8

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