Susceptibility to oxidation of plasma low-density lipoprotein in X-linked adrenoleukodystrophy:: Effects of simvastatin treatment

被引：8

作者：

Di Biase, A

Salvati, S

Varí, R

Avellino, C

Sforza, F

Cappa, M

Masella, R

机构：

[1] Ist Super Sanita, Lab Metab & Pathol Biochem, Dept Metab & Pathol Biochem, I-00161 Rome, Italy

[2] IRCCS Palidoro, Bambino Gesu Children Hosp, Dept Endocrinol, Rome, Italy

来源：

MOLECULAR GENETICS AND METABOLISM | 2000年 / 71卷 / 04期

关键词：

adrenoleukodystrophy; adrenomyeloneuropathy; asymptomatic; low-density lipoprotein; oxidizability; simvastatin;

D O I：

10.1006/mgme.2000.3100

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This paper shows for the first time the higher oxidizability of low-density lipoprotein (LDL) in plasma from adrenoleukodystrophy (ALD) patients compared to that of control subjects. LDL oxidation susceptibility was assessed by conjugate diene formation, hydroperoxide and lipoperoxide formation, and electrophoretic mobility. Simvastatin therapy, an HMG-CoA reductase inhibitor, seems to be a protective pharmacological agent against the higher oxidizability of LDL in plasma from ALD patients. (C) 2000 Academic Press.

引用

页码：651 / 655

页数：5

共 27 条

[1] COMPARISON OF GEMFIBROZIL VERSUS SIMVASTATIN IN FAMILIAL COMBINED HYPERLIPIDEMIA AND EFFECTS ON APOLIPOPROTEIN-B-CONTAINING LIPOPROTEINS, LOW-DENSITY-LIPOPROTEIN SUBFRACTION PROFILE, AND LOW-DENSITY-LIPOPROTEIN OXIDIZABILITY [J].