Borna disease virus

被引：46

作者：

Jordan, I

Lipkin, WI

机构：

[1] Univ Calif Irvine, Dept Neurol, Emerging Dis Lab, Irvine, CA 92697 USA

[2] Univ Calif Irvine, Dept Microbiol, Irvine, CA 92697 USA

[3] Univ Calif Irvine, Dept Mol Genet, Irvine, CA 92697 USA

来源：

REVIEWS IN MEDICAL VIROLOGY | 2001年 / 11卷 / 01期

关键词：

D O I：

10.1002/rmv.300

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Borna disease virus (BDV) is unique amongst animal RNA viruses in its molecular biology and capacity to cause persistent, noncytolytic CNS-infection in a wide variety of host species. Unlike other non-segmented negative-strand RNA animal viruses, BDV replicates in the nucleus of the host cell where splicing is employed for expression of a very compact genome. Epidemiological studies indicate a broad host range and geographical distribution, and some investigators have proposed that human infection may result in neuropsychiatric disorders. Experimental Borna disease in neonatal and adult rats provides an intriguing model for immune-mediated disturbances of brain development and function. Copyright (C) 2001 John Wiley & Sons, Ltd.

引用

页码：37 / 57

页数：21

共 183 条

[1]

AMSTERDAM JD, 1985, ARCH GEN PSYCHIAT, V42, P1093

[2] PERSISTENT BORNA VIRUS-INFECTION IN ADULT HAMSTERS [J].