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The steroidogenic acute regulatory protein as a target of endocrine disruption in male reproduction

被引：42
作者：
Clark, Barbara J. [1 ]
Cochrum, Renate K. [1 ]
机构：
[1] Univ Louisville, Ctr Genet & Mol Med, Dept Biochem & Mol Biol, Louisville, KY 40202 USA
来源：
DRUG METABOLISM REVIEWS | 2007年 / 39卷 / 2-3期
关键词：
StAR; Leydig cell; steroidogenesis; endocrine disruptor;
D O I：
10.1080/03602530701519151
中图分类号：
R9 [药学];
学科分类号：
1007 [药学];
摘要：
Development of the adult male reproductive tract requires proper spatial-temporal expression of the sex hormones testosterone and estrogen during fetal developmental stages and at puberty. Exogenous agents that disrupt the production and/or actions of the testosterone and estrogen and cause aberrant reproductive tract development can be thought of as endocrine disruptors (ED). This review will focus on the impact of ED on testosterone production by Leydig cells during fetal development and in the adult. In particular, the genes encoding the steroidogenic acute regulatory protein (StAR) and cytochrome P450 17 alpha hydroxylase/17,20 lyase (CYP17A1) within the steroid hormone biosynthetic pathway are highlighted as ED targets. We begin with an overview of steroidogenesis and regulation of StAR then summarize the published literature on the effects of diethylstibesterol, phthalate esters, and arsenite on male reproduction with a focus on the expression and function of StAR.
引用
收藏
页码：353 / 370
页数：18
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