Prompt and durable hematopoietic reconstitution by unrelated cord blood transplantation in a child with Fanconi anemia

被引：7

作者：

Yoshimasu, T

Tanaka, R

Suenobu, S

Yagasaki, H

Yoshino, H

Ueda, T

Hisakawa, H

Ishii, T

Mitsui, T

Ebihara, Y

Manabe, A

Iseki, T

Maekawa, T

Nakahata, T

Asano, S

Tsuji, K

机构：

[1] Univ Tokyo, Inst Med Sci, Dept Pediat Hematol Oncol, Tokyo, Japan

[2] Univ Tokyo, Inst Med Sci, Dept Cell Transfus, Tokyo, Japan

[3] Univ Tokyo, Inst Med Sci, Dept Hematol Oncol, Tokyo, Japan

来源：

BONE MARROW TRANSPLANTATION | 2001年 / 27卷 / 07期

关键词：

Fanconi anemia; unrelated cord blood transplantation;

D O I：

10.1038/sj.bmt.1702876

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

We describe here the case of an 8-year-old girl with Fanconi anemia (FA) whose hematopoiesis was successfully restored by unrelated umbilical cord blood (UCB) transplantation. The patient became resistant to androgen therapy, and developed intracranial hemorrhage and dyserythropoiesis. Her hematopoietic recovery after the transplantation was excellent and a complete chimerism has been durably maintained. UCB should be considered as a stem cell source for transplantation when a patient with FA does not have an HLA-identical unaffected sibling donor.

引用

页码：767 / 769

页数：3

共 23 条

[1]

ALTER BP, 1998, HEMATOLOGY INFANCY C, V1, P237

[2]

BALDUZZI A, 1995, BLOOD, V86, P3247

[3] Unrelated donor bone marrow transplantation for children with acute leukemia [J].

Davies, SM ;

Wagner, JE ;

Shu, XO ;

Blazar, BR ;

Katsanis, E ;

Orchard, PJ ;

Kersey, JH ;

Dusenbery, KE ;

Weisdorf, DJ ;

McGlave, PB ;

Ramsay, NKC .

JOURNAL OF CLINICAL ONCOLOGY, 1997, 15 (02) :557-565

[4] The IVS4+4 A to T mutation of the Fanconi anemia gene FANCC is not associated with a severe phenotype in Japanese patients [J].

Futaki, M ;

Yamashita, T ;

Yagasaki, H ;

Toda, T ;

Yabe, M ;

Kato, S ;

Asano, S ;

Nakahata, T .

BLOOD, 2000, 95 (04) :1493-1498

[5]

Gibson RA, 1996, HUM MUTAT, V8, P140, DOI 10.1002/(SICI)1098-1004(1996)8:2<140::AID-HUMU6>3.0.CO

[6]

2-F

[7] Outcome of cord-blood transplantation from related and unrelated donors [J].

Gluckman, E ;

Rocha, V ;

BoyerChammard, A ;

Locatelli, F ;

Arcese, W ;

Pasquini, R ;

Ortega, J ;

Souillet, G ;

Ferreira, E ;

Laporte, JP ;

Fernandez, M ;

Chastang, C .

NEW ENGLAND JOURNAL OF MEDICINE, 1997, 337 (06) :373-381

[8]

GLUCKMAN E, 1995, BLOOD, V86, P2856

[9] RADIOSENSITIVITY IN FANCONI ANEMIA - APPLICATION TO THE CONDITIONING REGIMEN FOR BONE-MARROW TRANSPLANTATION [J].

GLUCKMAN, E ;

DEVERGIE, A ;

DUTREIX, J .

BRITISH JOURNAL OF HAEMATOLOGY, 1983, 54 (03) :431-440

[10] BONE-MARROW TRANSPLANTATION IN FANCONI ANEMIA [J].

GLUCKMAN, E ;

DEVERGIE, A ;

SCHAISON, G ;

BUSSEL, A ;

BERGER, R ;

SOHIER, J ;

BERNARD, J .

BRITISH JOURNAL OF HAEMATOLOGY, 1980, 45 (04) :557-564

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