The first direct enzymatic hydrolysis of alicyclic β-amino esters:: A route to enantiopure cis and trans β-amino acids

被引：44

作者：

Forro, Eniko ^{[1
]}

Fueloep, Ferenc ^{[1
]}

机构：

[1] Univ Szeged, Inst Pharmaceut Chem, H-6701 Szeged, Hungary

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2007年 / 13卷 / 22期

关键词：

amino acids; cispentacin enantioselectivity; enzymes; hydrolysis;

D O I：

10.1002/chem.200700257

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first direct enzymatic method is reported for the synthesis of cis and trans P-amino acid enantiomers through the lipase-catalyzed enantioselective hydrolysis of alicyclic beta-amino esters in organic media. High enantioselectivities (E usually > 100) were observed when the Candida antarctica lipase B catalyzed reactions were performed with H2O (0.5 equivalents) in iPr(2)O at 65 degrees C. The resolved products, obtained in good yields (>= 42%), could be easily separated.

引用

页码：6397 / 6401

页数：5

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