Quinazolinethiones and quinazolinediones, novel inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure-activity relationships

被引：53

作者：

Buckley, GM ^{[1
]}

Davies, N ^{[1
]}

Dyke, HJ ^{[1
]}

Gilbert, PJ ^{[1
]}

Hannah, DR ^{[1
]}

Haughan, AF ^{[1
]}

Hunt, CA ^{[1
]}

Pitt, WR ^{[1
]}

Profit, RH ^{[1
]}

Ray, NC ^{[1
]}

Richard, MD ^{[1
]}

Sharpe, A ^{[1
]}

Taylor, AJ ^{[1
]}

Whitworth, JM ^{[1
]}

Williams, SC ^{[1
]}

机构：

[1] Celltech R&D, Cambridge CB1 6GS, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 03期

关键词：

D O I：

10.1016/j.bmcl.2004.11.015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The development of a series of novel quinazolinethiones and quinazolinediones as inhibitors of inosine monophosphate dehydrogenase (IMPDH) is described. The synthesis, in vitro inhibitory values for IMPDH II and in vitro inhibitory value for PBMC proliferation are discussed. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：751 / 754

页数：4

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