Solid-phase synthesis of 5,6-dihydropyrimidine-2,4-diones

被引：57

作者：

Kolodziej, SA ^{[1
]}

Hamper, BC ^{[1
]}

机构：

[1] MONSANTO CO,CEREGEN DIV,ST LOUIS,MO 63167

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 30期

关键词：

D O I：

10.1016/0040-4039(96)01103-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 1,3-disubstituted-5,6-dihydropyrimidine- 1 are prepared by solid phase organic chemistry using a cyclization-cleavage strategy from readily available amines and isocyanates. An acrylate ester of Wangs resin is treated with primary amines to afford N-substituted beta-aminoesters followed by treatment with isocyanates to afford beta-ureido ester 4. Cyclization-cleavage of the bound ureido ester under acidic conditions gave direct formation of 5,6-dihydropyrimidinedione 1. Copyright (C) 1996 Elsevier Science Ltd

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页码：5277 / 5280

页数：4

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