Preconditioning and Stem Cell Survival

被引：97

作者：

Haider, Husnain Kh ^{[1
]}

Ashraf, Muhammad ^{[1
]}

机构：

[1] Univ Cincinnati, Dept Pathol & Lab Med, Cincinnati, OH 45267 USA

来源：

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2010年 / 3卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Ischemia; Myocardial Infarction; Preconditioning; Stem Cells; ENDOTHELIAL PROGENITOR CELLS; PROTEIN-KINASE-C; ACUTE MYOCARDIAL-INFARCTION; PRESERVES CARDIAC-FUNCTION; MYOBLAST TRANSFER THERAPY; MARROW-DERIVED CELLS; ISCHEMIC RAT HEARTS; LONG-TERM SURVIVAL; K-ATP CHANNELS; OXIDATIVE STRESS;

D O I：

10.1007/s12265-009-9161-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The harsh ischemic and cytokine-rich microenvironment in the infarcted myocardium, infiltrated by the inflammatory and immune cells, offers a significant challenge to the transplanted donor stem cells. Massive cell death occurs during transplantation as well as following engraftment which significantly lowers the effectiveness of the heart cell therapy. Various approaches have been adopted to overcome this problem nevertheless with multiple limitations with each of these current approaches. Cellular preconditioning and reprogramming by physical, chemical, genetic, and pharmacological manipulation of the cells has shown promise and "prime" the cells to the "state of readiness" to withstand the rigors of lethal ischemia in vitro as well as posttransplantation. This review summarizes the past and present novel approaches of ischemic preconditioning, pharmacological and genetic manipulation using preconditioning mimetics, recombinant growth factor protein treatment, and reprogramming of stem cells to overexpress survival signaling molecules, microRNAs, and trophic factors for intracrine, autocrine, and paracrine effects on cytoprotection.

引用

页码：89 / 102

页数：14

共 127 条

[1] Stromal cell-derived factor-1α plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury [J].

Abbott, JD ;

Huang, Y ;

Liu, D ;

Hickey, R ;

Krause, DS ;

Giordano, FJ .

CIRCULATION, 2004, 110 (21) :3300-3305

[2]

ADDYA S, 2001, J MOL CELL CARDIOL, V38, P345

[3]

AFZAL MR, 2009, ANTIOXIDANT IN PRESS

[4] Cardiac protection by mitoKATP channels is dependent on Akt translocation from cytosol to mitochondria during late preconditioning [J].

Ahmad, Nauman ;

Wang, Yigang ;

Haider, Khawaja Husnain ;

Wang, Boyu ;

Pasha, Zeeshan ;

Uzun, Oezge ;

Ashraf, Muhammad .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2006, 290 (06) :H2402-H2408

[5] Mitochondrial ATP-sensitive potassium channels inhibit apoptosis induced by oxidative stress in cardiac cells [J].

Akao, M ;

Ohler, A ;

O'Rourke, B ;

Marbán, E .

CIRCULATION RESEARCH, 2001, 88 (12) :1267-1275

[6] Hypoxic preconditioning augments efficacy of human endothelial progenitor cells for therapeutic neovascularization [J].

Akita, T ;

Murohara, T ;

Ikeda, H ;

Sasaki, KI ;

Shimada, T ;

Egami, K ;

Imaizumi, T .

LABORATORY INVESTIGATION, 2003, 83 (01) :65-73

[7] Cardiac regeneration [J].

Anversa, P ;

Leri, A ;

Kajstura, J .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 47 (09) :1769-1776

[8] Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization [J].

Asahara, T ;

Chen, DH ;

Takahashi, T ;

Fujikawa, K ;

Kearney, M ;

Magner, M ;

Yancopoulos, GD ;

Isner, JM .

CIRCULATION RESEARCH, 1998, 83 (03) :233-240

[9] Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy [J].

Askari, AT ;

Unzek, S ;

Popovic, ZB ;

Goldman, CK ;

Forudi, F ;

Kiedrowski, M ;

Rovner, A ;

Ellis, SG ;

Thomas, JD ;

DiCorleto, PE ;

Topol, EJ ;

Penn, MS .

LANCET, 2003, 362 (9385) :697-703

[10] Enhancement of the functional benefits of skeletal myoblast transplantation by means of coadministration of hypoxia-inducible factor 1α [J].

Azarnoush, K ;

Maurel, A ;

Sebbah, L ;

Carrion, C ;

Bissery, A ;

Mandet, C ;

Pouly, J ;

Bruneval, P ;

Hagège, AA ;

Menasché, P .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2005, 130 (01) :173-179

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