Matrix Gla protein and osteopontin genetic associations with coronary artery calcification and bone density: the CARDIA study

被引：37

作者：

Taylor, BC

Schreiner, PJ

Doherty, TM

Fornage, M

Carr, JJ

Sidney, S

机构：

[1] Vet Adm Med Ctr, Ctr Chron Dis Outcomes Res, Minneapolis, MN 55417 USA

[2] Univ Minnesota, Sch Publ Hlth, Div Epidemiol, Minneapolis, MN 55455 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Cedars Sinai Med Ctr, Dept Med,Burns & Allen Res Inst, Los Angeles, CA USA

[4] Univ Texas, Hlth Sci Ctr, Inst Mol Med, Houston, TX USA

[5] Wake Forest Univ, Dept Radiol, Winston Salem, NC 27109 USA

[6] Kaiser Permanente Med Care Program, Div Res, Oakland, CA 94611 USA

来源：

HUMAN GENETICS | 2005年 / 116卷 / 06期

关键词：

D O I：

10.1007/s00439-005-1258-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A role for matrix proteins has previously been proposed in the pathogenesis of arterial calcification in the setting of atherosclerosis, and a link has been suggested between osteoporosis and arterial calcification. Our aim has been to investigate whether matrix Gla protein (MGP) T-138C, osteopontin (SPP1) T-443C, and Asp94Asp single nucleotide polymorphisms are associated with the development of arterial calcification and bone density. The individual effects of the MGP and SPP1 polymorphisms with coronary calcification are weak and not statistically significant. Bone mineral density differences at both the hip and spine do not vary statistically by genotype for any of the polymorphisms studied. Given the significant role of both MGP and SPP1 in arteriosclerosis, further research in higher risk, older populations are needed to determine fully the way in which MGP and SPP1 polymorphisms are associated with disease.

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页码：525 / 528

页数：4

相关论文

共 10 条

[1] The involvement of matrix glycoproteins in vascular calcification and fibrosis: an immunohistochemical study [J].

Canfield, AE ;

Farrington, C ;

Dziobon, MD ;

Boot-Handford, RP ;

Heagerty, AM ;

Kumar, SN ;

Roberts, ISD .

JOURNAL OF PATHOLOGY, 2002, 196 (02) :228-234

[2] Calcified coronary artery plaque measurement with cardiac CT in population-based studies: Standardized protocol of Multi-Ethnic Study of Atherosclerosis (MESA) and Coronary Artery Risk Development in Young Adults (CARDIA) study [J].

Carr, JJ ;

Nelson, JC ;

Wong, ND ;

McNitt-Gray, M ;

Arad, Y ;

Jacobs, DR ;

Sidney, S ;

Bild, DE ;

Williams, OD ;

Detrano, RC .

RADIOLOGY, 2005, 234 (01) :35-43

[3] Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques [J].

Dhore, CR ;

Cleutjens, JPM ;

Lutgens, E ;

Cleutjens, KBJM ;

Geusens, PPM ;

Kitslaar, PJEHM ;

Tordoir, JHM ;

Spronk, HMH ;

Vermeer, C ;

Daemen, MJAP .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2001, 21 (12) :1998-2003

[4] Molecular, endocrine, and genetic mechanisms of arterial calcification [J].

Doherty, TM ;

Fitzpatrick, LA ;

Inoue, D ;

Qiao, JH ;

Fishbein, MC ;

Detrano, RC ;

Shah, PK ;

Rajavashisth, TB .

ENDOCRINE REVIEWS, 2004, 25 (04) :629-672

[5] CARDIA - STUDY DESIGN, RECRUITMENT, AND SOME CHARACTERISTICS OF THE EXAMINED SUBJECTS [J].

FRIEDMAN, GD ;

CUTTER, GR ;

DONAHUE, RP ;

HUGHES, GH ;

HULLEY, SB ;

JACOBS, DR ;

LIU, K ;

SAVAGE, PJ .

JOURNAL OF CLINICAL EPIDEMIOLOGY, 1988, 41 (11) :1105-1116

[6] Polymorphisms in the osteopontin promoter affect its transcriptional activity [J].

Giacopelli, F ;

Marciano, R ;

Pistorio, A ;

Catarsi, P ;

Canini, S ;

Karsenty, G ;

Ravazzolo, R .

PHYSIOLOGICAL GENOMICS, 2004, 20 (01) :87-96

[7] Matrix Gla protein is associated with coronary artery calcification as assessed by electron-beam computed tomography [J].

Jono, S ;

Ikari, J ;

Vermeer, C ;

Dissel, P ;

Hasegawa, K ;

Shioi, A ;

Taniwaki, H ;

Kizu, A ;

Nishizawa, K ;

Saito, S .

THROMBOSIS AND HAEMOSTASIS, 2004, 91 (04) :790-794

[8] Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein [J].

Luo, GB ;

Ducy, P ;

McKee, MD ;

Pinero, GJ ;

Loyer, E ;

Behringer, RR ;

Karsenty, G .

NATURE, 1997, 386 (6620) :78-81

[9] Inactivation of the osteopontin gene enhances vascular calcification of matrix Gla protein-deficient mice: Evidence for osteopontin as an inducible inhibitor of vascular calcification in vivo [J].

Speer, MY ;

McKee, MD ;

Guldberg, RE ;

Liaw, L ;

Yang, HY ;

Tung, E ;

Karsenty, G ;

Giachelli, CM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (08) :1047-1055

[10]

TAYLOR BC, 2004, DISS ABSTR INT B, V65, P2899