ERG gene rearrangements are common in prostatic small cell carcinomas

被引：164

作者：

Lotan, Tamara L. ^{[1
]}

Gupta, Nilesh S. ^{[2
]}

Wang, Wenle ^{[1
]}

Toubaji, Antoun ^{[1
]}

Haffner, Michael C. ^{[3
]}

Chaux, Alcides ^{[1
]}

Hicks, Jessica L. ^{[1
]}

Meeker, Alan K. ^{[1
]}

Bieberich, Charles J. ^{[4
]}

De Marzo, Angelo M. ^{[1
,3
,5
]}

Epstein, Jonathan I. ^{[1
,3
,5
]}

Netto, George J. ^{[1
,3
,5
]}

机构：

[1] Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21231 USA

[2] Henry Ford Hosp, Dept Pathol, Detroit, MI 48202 USA

[3] Johns Hopkins Med Inst, Dept Oncol, Baltimore, MD 21231 USA

[4] Univ Maryland Baltimore Cty, Dept Biol Sci, Baltimore, MD 21228 USA

[5] Johns Hopkins Med Inst, Dept Urol, Baltimore, MD 21231 USA

来源：

MODERN PATHOLOGY | 2011年 / 24卷 / 06期

关键词：

androgen receptor; ERG; gene fusion; NKX3-1; prostatic adenocarcinoma; small cell carcinoma; TMPRSS2-ERG; NEUROENDOCRINE CARCINOMA; FUSION; CANCER; TMPRSS2; ADENOCARCINOMA; ABERRATIONS; DIAGNOSIS;

D O I：

10.1038/modpathol.2011.7

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Small cell carcinoma of the prostate is a rare subtype with an aggressive clinical course. Despite the frequent occurrence of ERG gene rearrangements in acinar carcinoma, the incidence of these rearrangements in prostatic small cell carcinoma is unclear. In addition, molecular markers to distinguish prostatic small cell carcinomas from lung and bladder small cell carcinomas may be clinically useful. We examined the occurrence of ERG gene rearrangements by fluorescence in situ hybridization in prostatic, bladder and lung small cell carcinomas. We also examined the expression of ERG, androgen receptor (AR) and NKX3-1 by immunohistochemistry in prostatic cases. Overall, 45% (10/22) of prostatic small cell carcinoma cases harbored ERG rearrangements, whereas no cases of bladder or lung small cell carcinomas showed ERG rearrangement (0/12 and 0/13, respectively). Of prostatic small cell carcinoma cases, 80% (8/10) showed ERG deletion and 20% (2/10) showed ERG translocation. In 83% (5/6) of prostatic small cell carcinoma cases in which a concurrent conventional prostatic acinar carcinoma component was available for analysis, there was concordance for the presence/absence of ERG gene rearrangement between the different subtypes. ERG, AR and NKX3-1 protein expression was detected in a minority of prostatic small cell carcinoma cases (23, 27 and 18%, respectively), while these markers were positive in the majority of concurrent acinar carcinoma cases (66, 83 and 83%, respectively). The presence of ERG rearrangements in nearly half of the prostatic small cell carcinomas is a similar rate of rearrangement to that found in prostatic acinar carcinomas. Furthermore, the high concordance rate of ERG rearrangement between the small cell and acinar components in a given patient supports a common origin for these two subtypes of prostate cancer. Finally, the absence of ERG rearrangement in bladder or lung small cell carcinomas highlights the utility of detecting ERG rearrangement in small cell carcinomas of unknown primary for establishing prostatic origin. Modern Pathology (2011) 24, 820-828; doi:10.1038/modpathol.2011.7; published online 18 February 2011

引用

页码：820 / 828

页数：9

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