The role of Toll-like receptors in combating mycobacteria

被引：111

作者：

Krutzik, SR ^{[1
]}

Modlin, RL ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Microbiol & Immunol, Div Dermatol, David Geffen Sch Med, Los Angeles, CA 90095 USA

来源：

SEMINARS IN IMMUNOLOGY | 2004年 / 16卷 / 01期

关键词：

innate immunity; intracellular; mycobacteria; TLR; Toll;

D O I：

10.1016/j.smim.2003.10.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the battle against infections with mycobacteria, the body employs components of both the innate and adaptive arms of the immune system. Toll-like receptors (TLRs) mediate the activation of cells of the innate immune system leading to dynamic functions including direct anti-microbial activity, induction of cytokine secretion, triggering dendritic cell maturation, and triggering apoptosis. Furthermore, TLR activation is capable of modulating the adaptive immune response with a bias towards a Th1 T-cell response. However, the activation of TLRs by mycobacteria may also provide a means of immune evasion. Therefore, the modulation of TLR activation can influence the ability to properly destroy invading pathogens such as mycobacteria. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：35 / 41

页数：7

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