Protective effects of an extract of young radish (Raphanus sativus L) cultivated with sulfur (sulfur-radish extract) and of sulforaphane on carbon tetrachloride-induced hepatotoxicity

被引：54

作者：

Baek, Seung-Hae ^{[1
,2
]}

Park, Min ^{[1
,2
]}

Suh, Jae-Hee ^{[3
]}

Choi, Hye-Seon ^{[1
,2
]}

机构：

[1] Univ Ulsan, Dept Biol Sci, Ulsan 680749, South Korea

[2] Univ Ulsan, Immunomodulat Res Ctr, Ulsan 680749, South Korea

[3] Ulsan Univ Hosp, Dept Pathol, Ulsan 682714, South Korea

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2008年 / 72卷 / 05期

关键词：

phase; 2; enzyme; radish; sulfur; sulforaphane; CCl4-induced hepatotoxicity;

D O I：

10.1271/bbb.70545

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The protective effects of an extract of young radish (Raphanus sativus L) cultivated with sulfur (sulfur-radish extract) and of sulforaphane, an isothiocyanate, on carbon tetrachloride (CCl4)-induced liver injury were observed in mice. CCl4 produced a marked increase in the serum level of alanine aminotransferase (ALT), primed lipid peroxidation, and resulted in intense necrosis due to oxidative stress. Oral administration of the sulfur-radish extract and of sulforaphane after CCl4-induced liver injury both decreased the serum level of ALT, reduced the necrotic zones, inhibited lipid peroxidation, and induced phase 2 enzymes without affecting cytochrome P450-2E1 (CYP2E1). These results suggest that the administration of the sulfur-radish extract and of sulforaphane may partially prevent CCl4-induced hepatotoxicity, possibly by indirectly acting as an antioxidant by improving the detoxification system.

引用

页码：1176 / 1182

页数：7

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