Recombinant OprF-OprI as a vaccine against Pseudomonas aeruginosa infections

被引：64

作者：

Baumann, U

Mansouri, E

von Specht, BU

机构：

[1] Chirurg Univ Klin Freiburg, Chirurg Forsch, D-79106 Freiburg, Germany

[2] Hannover Med Sch, Abt Padiatr Pneumonol & Neonatal, D-30623 Hannover, Germany

来源：

VACCINE | 2004年 / 22卷 / 07期

关键词：

Pseudomonas aeruginosa; OprF-OprI;

D O I：

10.1016/j.vaccine.2003.11.029

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A vaccine against Pseudomonas aeruginosa based on recombinant outer membranes has been developed. After intramuscularly injecting into patients with severe burns, antibodies against P. aeruginosa were induced. Vaccination was well tolerated. Intranasal application of the vaccine into volunteers, induced specific s-IgA antibodies. We conclude that the newly developed vaccine may be suitable for protection of the main risk groups of P. aeruginosa infections. In particular, for the protection of burn patients and patients with cystic fibrosis. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：840 / 847

页数：8

共 71 条

[1] IMMUNIZATION AGAINST PSEUDOMONAS IN INFECTION AFTER THERMAL INJURY [J].