Is blood homocysteine elevated in migraine?

被引:48
作者
Hering-Hanit, R [1 ]
Gadoth, N
Yavetz, A
Gavendo, S
Sela, B
机构
[1] Meir Hosp, Headache Unit, Sapir Med Ctr, IL-44281 Kefar Sava, Israel
[2] Meir Hosp, Dept Neurol, Sapir Med Ctr, IL-44281 Kefar Sava, Israel
[3] Tel Aviv Univ, Inst Chem Pathol, Sheba Med Ctr, IL-69978 Tel Aviv, Israel
[4] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel
来源
HEADACHE | 2001年 / 41卷 / 08期
关键词
homocysteine; migraine; stroke; hypercoagulable;
D O I
10.1046/j.1526-4610.2001.01143.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective.-To determine total serum homocysteine levels in a large group of patients with migraine with and without aura. Background.-Hypercoagulable state is a known risk factor for stroke in the young. The existence of a hypercoagulable state has been postulated in migraine and homocysteinemia with young-onset stroke. To the best of our knowledge, blood homocysteine has not been studied in a significant number of patients with various forms of migraine. Methods.-Total serum homocysteine was measured with high-performance liquid chromatography in 78 patients with migraine and in 126 age- and sex-matched healthy volunteers. Results.-Seventy-eight patients aged 18 to 65 years were studied: 22 with migraine with aura and 56 with migraine without aura. Only 1 man had significantly elevated blood homocysteine (38.6 mu mol/L), while another had a borderline elevation (15.8 mu mol/L) (reference value for both sexes in our laboratory is 4 to 14 mu mol/L). Both patients suffered from migraine without aura. Conclusions.-Blood homocysteine is not elevated in migraine.
引用
收藏
页码:779 / 781
页数:3
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