Emotional reactivity in mice may not be inherited but influenced by parents

Heredity is often assimilated to genetic transmission of traits. However, some traits may be socially inherited. This has been described for maternal behaviour as well as for emotional reactivity in rodents such as rats or mice. The aim of the present study was to investigate further this idea using two backcrosses between CB6 or B6C females and C57BL/6 males. Indeed, the experimental groups are genetically identical but may be exposed to very different mothering types. When adults, the offspring were subjected to rodent emotional reactivity tests such as elevated plus maze and free exploration paradigm. Results show that CB6 x B6 males exhibit higher emotional reactivity than B6C x B6 and B6 males in all behavioural situations, but these effects are not seen in females. Contrarily to their offspring that show different reactivity even if sharing the same genetical background, CB6 and B6C females display quite identical emotional reactivity. A possible explanation is that emotional reactivity is induced by maternal behaviour rather than transmitted by the parents. (C) 2003 Elsevier Inc. All rights reserved.