Pulse pressure predicts cardiovascular risk in patients with type 2 diabetes mellitus

被引:75
作者
Cockcroft, JR [1 ]
Wilkinson, IB
Evans, M
McEwan, P
Peters, JR
Davies, S
Scanlon, MF
Currie, CJ
机构
[1] Univ Wales Coll Cardiff, Coll Med, Univ Hosp, Dept Cardiol, Cardiff CF14 4XN, Wales
[2] Univ Wales Coll Cardiff, Coll Med, Univ Hosp, Dept Diabet Endocrinol & Metab, Cardiff CF14 4XN, Wales
[3] Univ Cambridge, Addenbrookes Hosp, Dept Clin Pharmacol, Cambridge CB2 2QQ, England
关键词
cardiovascular risk; diabetes; pulse pressure;
D O I
10.1016/j.amjhyper.2005.05.009
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Background: Pulse pressure (PP), a marker of arterial stiffness, is a better predictor of coronary heart disease (CHD) risk than systolic blood pressure (SBP) or diastolic blood pressure (DBP) in older adults. Whether this is also true in subjects with type 2 diabetes, who are at increased risk for cardiovascular disease, is unknown. Methods: Data on 2911 type 2 diabetic subjects relating to blood pressure (BP), other risk factors, and cardiovascular events were abstracted from The Cardiff Diabetes Database. Logistic regression was used to assess the relationship among BP components and the risk of CHD, cerebrovascular (CVD), and peripheral vascular (PVD) events after correction for age, gender, cholesterol, and smoking status. Results: In the 4-year follow-up period there were 574 CHD, 168 CVD, and 157 PVD events. Both PP and SBP, but not DBP, were positively associated with the risk of all event types. However, PP emerged as the best predictor of CHD events, and SBP as the best predictor of CVD and PVD events. Total and HDL-cholesterol were the most important variables associated with PP after age. Conclusions: In summary, PP is abetter predictor of CHD events than SBP in persons with type 2 diabetes, but the converse is true for CVD and PVD. Ain J Hypertens 2005;18: 1463-1467 (D 2005 American Journal of Hypertension, Ltd.
引用
收藏
页码:1463 / 1467
页数:5
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