RIP3 Finds Partners in Crime

被引：46

作者：

Chan, Francis Ka-Ming ^{[1
]}

Baehrecke, Eric H. ^{[2
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Pathol, Worcester, MA 01505 USA

[2] Univ Massachusetts, Sch Med, Dept Canc Biol, Worcester, MA 01505 USA

来源：

CELL | 2012年 / 148卷 / 1-2期

关键词：

CELL-DEATH; NECROSIS;

D O I：

10.1016/j.cell.2011.12.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Programmed necrosis has long been recognized as a crucial component of animal development; however, the signaling pathway beyond the protein kinases RIP1 and RIP3 remains largely unknown. Sun et al. and Wang et al. now identify critical factors downstream of RIP1 and RIP3 in programmed necrosis, extending our understanding of this form of cell death.

引用

页码：17 / 18

页数：2

共 9 条

[1]

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation [J].

Cho, YoungSik ;

Challa, Sreerupa ;

Moquin, David ;

Genga, Ryan ;

Ray, Tathagat Dutta ;

Guildford, Melissa ;

Chan, Francis Ka-Ming .

CELL, 2009, 137 (06) :1112-1123

[2]

Identification of RIP1 kinase as a specific cellular target of necrostatins [J].

Degterev, Alexei ;

Hitomi, Junichi ;

Germscheid, Megan ;

Ch'en, Irene L. ;

Korkina, Olga ;

Teng, Xin ;

Abbott, Derek ;

Cuny, Gregory D. ;

Yuan, Chengye ;

Wagner, Gerhard ;

Hedrick, Stephen M. ;

Gerber, Scott A. ;

Lugovskoy, Alexey ;

Yuan, Junying .

NATURE CHEMICAL BIOLOGY, 2008, 4 (05) :313-321

[3]

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α [J].

He, Sudan ;

Wang, Lai ;

Miao, Lin ;

Wang, Tao ;

Du, Fenghe ;

Zhao, Liping ;

Wang, Xiaodong .

CELL, 2009, 137 (06) :1100-1111

[4]

The Loss of PGAM5 Suppresses the Mitochondrial Degeneration Caused by Inactivation of PINK1 in Drosophila [J].

Imai, Yuzuru ;

Kanao, Tomoko ;

Sawada, Tomoyo ;

Kobayashi, Yoshito ;

Moriwaki, Yasuhiro ;

Ishida, Yosuke ;

Takeda, Kohsuke ;

Ichijo, Hidenori ;

Lu, Bingwei ;

Takahashi, Ryosuke .

PLOS GENETICS, 2010, 6 (12) :1-14

[5]

The molecular regulation of programmed necrotic cell injury [J].

Moquin, David ;

Chan, Francis Ka-Ming .

TRENDS IN BIOCHEMICAL SCIENCES, 2010, 35 (08) :434-441

[6]

It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival [J].

Oberst, Andrew ;

Green, Douglas R. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2011, 12 (11) :757-763

[7]

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase [J].

Sun, Liming ;

Wang, Huayi ;

Wang, Zhigao ;

He, Sudan ;

Chen, She ;

Liao, Daohong ;

Wang, Lai ;

Yan, Jiacong ;

Liu, Weilong ;

Lei, Xiaoguang ;

Wang, Xiaodong .

CELL, 2012, 148 (1-2) :213-227

[8]

The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways [J].

Wang, Zhigao ;

Jiang, Hui ;

Chen, She ;

Du, Fenghe ;

Wang, Xiaodong .

CELL, 2012, 148 (1-2) :228-243

[9]

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis [J].

Zhang, Duan-Wu ;

Shao, Jing ;

Lin, Juan ;

Zhang, Na ;

Lu, Bao-Ju ;

Lin, Sheng-Cai ;

Dong, Meng-Qiu ;

Han, Jiahuai .

SCIENCE, 2009, 325 (5938) :332-336

← 1 →