Pharmaceutically active ionic liquids with solids handling, enhanced thermal stability, and fast release

被引：113

作者：

Bica, Katharina ^{[3
]}

Rodriguez, Hector ^{[4
]}

Gurau, Gabriela ^{[1
,2
]}

Cojocaru, O. Andreea ^{[1
,2
]}

Riisager, Anders ^{[5
,6
]}

Fehrmann, Rasmus ^{[5
,6
]}

Rogers, Robin D. ^{[1
,2
]}

机构：

[1] Univ Alabama, Ctr Green Mfg, Tuscaloosa, AL 35487 USA

[2] Univ Alabama, Dept Chem, Tuscaloosa, AL 35487 USA

[3] Vienna Univ Technol, Inst Appl Synthet Chem, A-1060 Vienna, Austria

[4] Univ Santiago de Compostela, Dept Chem Engn, E-15782 Santiago De Compostela, Spain

[5] Tech Univ Denmark, Dept Chem, DK-2800 Lyngby, Denmark

[6] Tech Univ Denmark, Ctr Catalysis & Sustainable Chem CSC, DK-2800 Lyngby, Denmark

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 44期

关键词：

MESOPOROUS SILICA; DRUG-DELIVERY;

D O I：

10.1039/c2cc30959a

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Pharmaceutically active compounds in ionic liquid form immobilized onto mesoporous silica are stable, easily handled solids, with fast and complete release from the carrier material when placed into an aqueous environment. Depending on specific ion-surface interactions, they may also exhibit improved thermal stability when compared to the non-adsorbed compounds.

引用

页码：5422 / 5424

页数：3

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