Effect of zinc or zinc plus arginine supplementation on antibody titre and lymphocyte subsets after influenza vaccination in elderly subjects: a randomized controlled trial

被引:65
作者
Provinciali, M
Montenovo, A
Di Stefano, G
Colombo, M
Daghetta, L
Cairati, M
Veroni, C
Cassino, R
Della Torre, F
Fabris, N
机构
[1] Italian Natl Res Ctr Aging, Gerontol Res Dept, Ctr Immunol, I-60121 Ancona, Italy
[2] Camillo Golgi Geriatr Inst, Abbiategrasso, Italy
[3] Univ Pavia, Policlin San Matteo, Haematol Inst, I-27100 Pavia, Italy
关键词
immune response; influenza vaccine; randomized controlled trial; zinc;
D O I
10.1093/ageing/27.6.715
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Objective: to evaluate whether oral supplementation with zinc or zinc/arginine increases the antibody response to influenza vaccine or modulates the lymphocyte phenotype in elderly subjects. Design: a randomized controlled trial with two supplemented groups and one control group. Setting: a community nursing home. Participants: 384 subjects aged 64-100 (mean age 82 years) examined in three separate studies. Intervention: oral supplementation with zinc (400 mg/day) or zinc plus arginine (4 g/day) for 60 days starting 15 days before influenza vaccination. The control groups received vaccine only. Measurements: haematological and nutritional indices, antibody titre against influenza viral antigens, lymphocyte phenotype. Results: supplementation with title or zinc plus arginine increased zinc plasma concentrations restoring the age-related impairment in zinc concentrations to values found in younger people. The antibody titre against influenza viral antigens was not increased in zinc or zinc/arginine supplemented groups in comparison with subjects receiving vaccine alone. The number of CD3, CD4 or CD8 lymphocytes was not affected by zinc or zinc/arginine supplementation. Conclusion: prolonged supplementation with zinc or zinc/arginine restores zinc plasma concentrations but is ineffective in inducing or ameliorating the antibody response after influenza vaccination in elderly subjects.
引用
收藏
页码:715 / 722
页数:8
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