Endothelial stem cells and precursors for tissue engineering: Cell source, differentiation, selection, and application

被引:73
作者
Kim, Saejeong [1 ]
Von Recum, Horst [1 ]
机构
[1] Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106 USA
关键词
D O I
10.1089/teb.2007.0304
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Endothelial cells are of great interest because of their potential in cell therapy for vascular diseases and ischemic tissue, tissue engineering for vascular grafts and vascularized tissue beds, and modeling for pharmaceutical transport across endothelial barriers. However, limited availability and proliferation capability of mature endothelial cells hampers development of these applications. Recent advances in stem cell technology have enabled researchers to derive endothelial or endothelial-like cells from stem cells or other precursor populations. The current state of these cell sources and their in vitro differentiation, selection, and applications are discussed in this review.
引用
收藏
页码:133 / 147
页数:15
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