Prospects for atomic resolution and neutron crystallography in drug design

被引：7

作者：

Coates, L

Myles, DAA

机构：

[1] Univ Southampton, Sch Biol Sci, Div Biochem & Mol Biol, Southampton SO16 7PX, Hants, England

[2] EMBL, Grenoble Outstn, F-38042 Grenoble 9, France

来源：

CURRENT DRUG TARGETS | 2004年 / 5卷 / 02期

关键词：

D O I：

10.2174/1389450043490613

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The number of protein crystal structures being refined to atomic resolution is increasing each year as well as the size of proteins being studied. There are currently 346 structures in the protein data bank which have been refined to or beyond atomic resolution. The benefits of atomic resolution X-ray data are discussed along with a number of structural examples of biomedically relevant proteins. The complementary role of neutron diffraction will also be discussed.

引用

收藏

页码：173 / 178

页数：6

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