New 1-amino-1,2-diphenylethanols as ligands for the enantioselective addition of alkyllithiums to benzaldehyde

被引：25

作者：

Schön, M ^{[1
]}

Naef, R ^{[1
]}

机构：

[1] Novartis Pharma AG, CH-4002 Basel, Switzerland

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 01期

关键词：

D O I：

10.1016/S0957-4166(98)00473-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

In the presence of equimolar amounts of lithium alkoxides derived from N-substituted 2-amino-1,2-diphenylethanols, alkyllithium reagents add to benzaldehyde to furnish optically active secondary alcohols with enantiomeric excesses of up to 86%. The best results were obtained using the N-isopropyl-N-methyl substituted amin-oalcohol. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：169 / 176

页数：8

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