In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A

被引：121

作者：

Ishimoto, Hidekazu ^{[1
]}

Shibata, Mari ^{[2
]}

Myojin, Yuki ^{[3
]}

Ito, Hideyuki ^{[1
,3
]}

Sugimoto, Yukio ^{[2
]}

Tai, Akihiro ^{[4
]}

Hatano, Tsutomu ^{[1
]}

机构：

[1] Okayama Univ, Dept Pharmacognosy, Div Pharmaceut Sci, Grad Sch Med Dent & Pharmaceut Sci,Kita Ku, Okayama 7008530, Japan

[2] Okayama Univ, Dept Pharmacol, Div Pharmaceut Sci, Grad Sch Med Dent & Pharmaceut Sci,Kita Ku, Okayama 7008530, Japan

[3] Okayama Univ, Dept Pharmacognosy, Fac Pharmaceut Sci, Kita Ku, Okayama 7008530, Japan

[4] Prefectural Univ Hiroshima, Fac Life & Environm Sci, Hiroshima 7270023, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 19期

关键词：

Ellagitannin; Urolithin A; Antioxidant activity; Anti-inflammatory activity; ABSORBENCY CAPACITY ASSAY; ELLAGIC ACID; POMEGRANATE JUICE; HUMAN PLASMA; TANNINS; INFLAMMATION; RATS; BIOAVAILABILITY; IDENTIFICATION; CONSUMPTION;

D O I：

10.1016/j.bmcl.2011.07.086

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Urolithin A is a major metabolite produced by rats and humans after consumption of pomegranate juice or pure ellagitannin geraniin. In this study, we investigated the anti-inflammatory effect of urolithin A on carrageenan-induced paw edema in mice. The volume of paw edema was reduced at 1 h after oral administration of urolithin A. In addition, plasma in treated mice exhibited significant oxygen radical antioxidant capacity (ORAC) scores with high plasma levels of the unconjugated form at 1 h after oral administration of urolithin A. These results indicate strong associations among plasma urolithin A levels, the plasma ORAC scores, and anti-inflammatory effects and may help explain a mechanism by which ellagitannins confer protection against inflammatory diseases. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：5901 / 5904

页数：4

共 32 条

[1]

OXYGEN-RADICAL ABSORBENCY CAPACITY ASSAY FOR ANTIOXIDANTS [J].