Sex differences in nitrite/nitrate levels and antioxidant defense in rat brain

被引：56

作者：

Taskiran, D

Kutay, FZ

Sozmen, E

Pogun, S

机构：

[1] EGE UNIV, CTR BRAIN RES, DEPT PHYSIOL, TR-35100 IZMIR, TURKEY

[2] EGE UNIV, CTR BRAIN RES, DEPT BIOCHEM, TR-35100 IZMIR, TURKEY

[3] TUBITAK, BASIC NEUROSCI RES UNIT, TR-35100 IZMIR, TURKEY

来源：

NEUROREPORT | 1997年 / 8卷 / 04期

关键词：

antioxidant; catalase; nitrate; nitric oxide; nitrite; sex differences; superoxide dismutase;

D O I：

10.1097/00001756-199703030-00013

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THIS Study assessed sex differences in stable metabolites of nitric oxide and major enzymes involved in antioxidant defense in various regions of rat brain. Nitrite/nitrate nitrate levels and activities of superoxide dismutase and catalase were determined in cortex, hippocampus, corpus striatum, midbrain and cerebellum of adult male and female Sprague-Dawley rats. Nitrite/nitrate levels were significantly higher in the cortex and the hippocampus of male than female rats, while catalase activity was higher in the cortex of females than in males. These sex differences may have significant effects on brain function in health and disease.

引用

页码：881 / 884

页数：4

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