Adaptive mutations, mutator DNA polymerases and genetic change strategies of pathogens

被引：66

作者：

McKenzie, GJ

Rosenberg, SM

机构：

[1] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Biochem, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2001年 / 4卷 / 05期

关键词：

D O I：

10.1016/S1369-5274(00)00255-1

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

'Adaptive' or 'stationary-phase' mutation is a collection of stress responses promoting mutations, some of which are advantageous. In 2000 and 2001, in Escherichia coli, adaptive gene amplification was documented, and a parallel adaptive point-mutation mechanism was linked to the error-prone DNA polymerase, DinB (pol IV). We suggest that DinB homologues may contribute to adaptive strategies of pathogens, including antigenic variation.

引用

页码：586 / 594

页数：9

共 79 条

[1] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].