Stem cells, cancer, and cancer stem cells

被引：7845

作者：

Reya, T

Morrison, SJ

Clarke, MF

Weissman, IL

机构：

[1] Stanford Univ, Sch Med, Dept Dev Biol, Stanford, CA 94305 USA

[2] Univ Michigan, Howard Hughes Med Inst, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA

[4] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA

来源：

NATURE | 2001年 / 414卷 / 6859期

关键词：

D O I：

10.1038/35102167

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Stem cell biology has come of age. Unequivocal proof that stem cells exist in the haematopoietic system has given way to the prospective isolation of several tissue-specific stem and progenitor cells, the initial delineation of their properties and expressed genetic programmes, and the beginnings of their utility in regenerative medicine. Perhaps the most important and useful property of stem cells is that of self-renewal. Through this property, striking parallels can be found between stem cells and cancer cells: tumours may often originate from the transformation of normal stem cells, similar signalling pathways may regulate self-renewal in stem cells and cancer cells, and cancer cells may include 'cancer stem cells'-rare cells with indefinite potential for self-renewal that drive tumorigenesis.

引用

页码：105 / 111

页数：7

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