Clinical importance of confirming or excluding the diagnosis of chronic graft-versus-host disease

被引:34
作者
Jacobsohn, DA
Montross, S
Anders, V
Vogelsang, GB
机构
[1] Johns Hopkins Univ, Sch Med, Dept Oncol & Pediat, Baltimore, MD USA
[2] Johns Hopkins Univ, Sch Med, Dept Oncol, Div Hematol Malignancies, Baltimore, MD 21205 USA
关键词
chronic GVHD; diagnosis; hematopoietic cell transplantation;
D O I
10.1038/sj.bmt.1703278
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Chronic graft-versus-host disease (cGVHD) is a major complication of allogeneic hematopoietic cell transplantation. The presentation of this disease is varied, and it requires histological confirmation for diagnosis. In addition, cGVHD can often mimic other diseases, and vice versa. We have conducted a retrospective analysis of 123 patients referred to the GVHD clinic at the Johns Hopkins Oncology Center from 1994 to 1998 with a diagnosis of active cGVHD. Of these, nine patients (7%) had no evidence of cGVHD, and 25 patients (20%) had inactive cGVHD. Many of these patients were found to have other processes accounting for their ongoing symptoms. We conclude that since the therapy for this disease has significant toxicities and since what appears to represent cGVHD may actually be another disease, correct diagnosis of cGVHD or exclusion of this diagnosis is essential.
引用
收藏
页码:1047 / 1051
页数:5
相关论文
共 22 条
  • [1] Pancreatic insufficiency in patients with chronic graft-versus-host disease
    Akpek, G
    Valladares, JL
    Lee, L
    Margolis, J
    Vogelsang, GB
    [J]. BONE MARROW TRANSPLANTATION, 2001, 27 (02) : 163 - 166
  • [2] ATKINSON K, 1982, BLOOD, V60, P714
  • [3] ATKINSON K, 1979, BLOOD, V53, P720
  • [4] ATKINSON K, 1990, BONE MARROW TRANSPL, V5, P69
  • [5] MARROW TRANSPLANTATION FROM HLA-MATCHED UNRELATED DONORS FOR TREATMENT OF HEMATOLOGIC MALIGNANCIES
    BEATTY, PG
    HANSEN, JA
    LONGTON, GM
    THOMAS, ED
    SANDERS, JE
    MARTIN, PJ
    BEARMAN, SI
    ANASETTI, C
    PETERSDORF, EW
    MICKELSON, EM
    PEPE, MS
    APPELBAUM, FR
    BUCKNER, CD
    CLIFT, RA
    PETERSEN, FB
    STEWART, PS
    STORB, RF
    SULLIVAN, KM
    TESLER, MC
    WITHERSPOON, RP
    [J]. TRANSPLANTATION, 1991, 51 (02) : 443 - 447
  • [6] Transplantation of bone marrow as compared with peripheral-blood cells from HLA-identical relatives in patients with hematologic cancers.
    Bensinger, WI
    Martin, PJ
    Storer, B
    Clift, R
    Forman, SJ
    Negrin, R
    Kashyap, A
    Flowers, MED
    Lilleby, K
    Chauncey, TR
    Storb, R
    Appelbaum, FR
    Rowley, S
    Heimfeld, S
    Blume, K
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (03) : 175 - 181
  • [7] Randomized trial of bone marrow versus lenograstim-primed blood cell allogeneic transplantation in patients with early-stage leukemia: A report from the Societe Francaise de Greffe de Moelle
    Blaise, D
    Kuentz, M
    Fortanier, C
    Bourhis, JH
    Milpied, N
    Sutton, L
    Jouet, JP
    Attal, M
    Bordigoni, P
    Cahn, JY
    Boiron, JM
    Schuller, MP
    Moatti, JP
    Michalle, M
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2000, 18 (03) : 537 - 546
  • [8] Durrant ST, 1999, BLOOD, V94, p608A
  • [9] Farmer E R, 1986, Adv Dermatol, V1, P173
  • [10] Pathophysiology and treatment of graft-versus-host disease
    Flowers, MED
    Kansu, E
    Sullivan, KM
    [J]. HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 1999, 13 (05) : 1091 - +