Propentofylline attenuates microglial reaction in the rat spinal cord induced by middle cerebral artery occlusion

被引：15

作者：

Wu, YP

McRae, A

Rudolphi, K

Ling, EA ^{[1
]}

机构：

[1] Natl Univ Singapore, Fac Med, Dept Anat, Singapore 119260, Singapore

[2] Univ W Indies, Dept Preclin Sci, St Augustine, Trinidad Tobago

[3] Hoechst AG, D-6230 Frankfurt, Germany

来源：

NEUROSCIENCE LETTERS | 1999年 / 260卷 / 01期

关键词：

propentofylline; adenosine; immunohistochemistry; microglial activation; focal cerebral ischaemia; lumbar spinal cord;

D O I：

10.1016/S0304-3940(98)00941-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study examines the effect of Propentofylline (PPF) on reactive microglia in the lumbar spinal cord in rats following focal cerebral ischaemia produced by permanent occlusion of the middle cerebral artery (MCA). Our results showed that daily treatment of PPF beginning at 24 h after MCA occlusion for 2 or 4 consecutive days markedly suppressed the microglial response as detected immunohistochemically with OX-42. The most dramatic effect was the prevention of transformation of ramified microglia into amoeboidic form as well as formation of perineuronal microglia in close association with the soma of motoneurons. This has greatly amplified the potentiality of PPF used as a neuroprotective drug against microglia-related neuron damage induced by cerebral ischaemia. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：17 / 20

页数：4

共 22 条

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