The angiogenic effect of tissue factor on tumors and wounds

被引：31

作者：

Nakagawa, K ^{[1
]}

Zhang, YM

Tsuji, H

Yoshizumi, M

Kasahara, T

Nishimura, H

Nawroth, PP

Nakagawa, M

机构：

[1] Kyoto Prefectural Univ Med, Dept Med 2, Kamigyo Ku, Kyoto 602, Japan

[2] Univ Heidelberg, Dept Med, D-6900 Heidelberg, Germany

来源：

SEMINARS IN THROMBOSIS AND HEMOSTASIS | 1998年 / 24卷 / 03期

关键词：

tissue factor (TF); vascular endothelial growth factor (VEGF); angiogenesis; tumor; wound healing;

D O I：

10.1055/s-2007-995843

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a novel function of tissue factor (TF) as an angiogenic factor in malignant and non-malignant cells and tissue. When methylcholanthrene A-induced murine fibrosarcoma (Meth-A sarcoma) was stably transfected with mouse TF (mTF) cDNA (pXT1 expression vector), its vascularization in vivo was significantly enhanced, whereas TF-antisense suppressed the vascularization and tumor growth. In vitro expression of vascular endothelial growth factor (VEGF) was enhanced with stable transfection of mTF (pcDNA3 expression vector) into a mouse fibroblast cell line (NIH3T3). Moreover, in vivo topical transfection of mTF (pcDNA3) showed an enhanced vascularization and healing in a diabetic mouse wound-healing model. This effect of TF as an angiogenic factor might be useful as an antitumor therapy against hypervascular tumors or as a novel agent against delayed wound healing.

引用

页码：207 / 210

页数：4

共 10 条

[1] Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation [J].

Bugge, TH ;

Xiao, Q ;

Kombrinck, KW ;

Flick, MJ ;

Holmback, K ;

Danton, HJS ;

Colbert, MC ;

Witte, DP ;

Fujikawa, K ;

Davie, EW ;

Degen, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (13) :6258-6263

[2] Role of tissue factor in embryonic blood vessel development [J].

Carmeliet, P ;

Mackman, N ;

Moons, L ;

Luther, T ;

Gressens, P ;

VanVlaenderen, I ;

Demunck, H ;

Kasper, M ;

Breier, G ;

Evrard, P ;

Muller, M ;

Risau, W ;

Edgington, T ;

Collen, D .

NATURE, 1996, 383 (6595) :73-75

[3] TUMOR VASCULAR-PERMEABILITY FACTOR STIMULATES ENDOTHELIAL-CELL GROWTH AND ANGIOGENESIS [J].

CONNOLLY, DT ;

HEUVELMAN, DM ;

NELSON, R ;

OLANDER, JV ;

EPPLEY, BL ;

DELFINO, JJ ;

SIEGEL, NR ;

LEIMGRUBER, RM ;

FEDER, J .

JOURNAL OF CLINICAL INVESTIGATION, 1989, 84 (05) :1470-1478

[4] EXPRESSION OF TISSUE FACTOR BY MELANOMA-CELLS PROMOTES EFFICIENT HEMATOGENOUS METASTASIS [J].

MUELLER, BM ;

REISFELD, RA ;

EDGINGTON, TS ;

RUF, W .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (24) :11832-11836

[5] VASCULAR ENDOTHELIAL GROWTH-FACTOR IS A POTENTIAL TUMOR ANGIOGENESIS FACTOR IN HUMAN GLIOMAS INVIVO [J].

PLATE, KH ;

BREIER, G ;

WEICH, HA ;

RISAU, W .

NATURE, 1992, 359 (6398) :845-848

[6] HEMOSTATIC ALTERATIONS IN CANCER-PATIENTS [J].

RICKLES, FR ;

LEVINE, M ;

EDWARDS, RL .

CANCER AND METASTASIS REVIEWS, 1992, 11 (3-4) :237-248

[7] BINDING OF HUMAN FACTOR VIIA TO TISSUE FACTOR INDUCES CYTOSOLIC CA2+ SIGNALS IN J82 CELLS, TRANSFECTED COS-1 CELLS, MADIN-DARBY CANINE KIDNEY-CELLS AND IN HUMAN ENDOTHELIAL-CELLS INDUCED TO SYNTHESIZE TISSUE FACTOR [J].

ROTTINGEN, JA ;

ENDEN, T ;

CAMERER, E ;

IVERSEN, JG ;

PRYDZ, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (09) :4650-4660

[8]

Toomey JR, 1996, BLOOD, V88, P1583

[9] TISSUE FACTOR CONTROLS THE BALANCE OF ANGIOGENIC AND ANTIANGIOGENIC PROPERTIES OF TUMOR-CELLS IN MICE [J].

ZHANG, YM ;

DENG, YH ;

LUTHER, T ;

MULLER, M ;

ZIEGLER, R ;

WALDHERR, R ;

STERN, DM ;

NAWROTH, PP .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 94 (03) :1320-1327

[10]

ZIONCHECK TF, 1992, J BIOL CHEM, V267, P3561

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