Current and Future Pharmacologic Treatment of Sarcopenia

被引：80

作者：

Rolland, Yves ^{[1
,2
]}

Onder, Graziano ^{[3
]}

Morley, John E. ^{[4
,5
]}

Gillette-Guyonet, Sophie ^{[1
,2
]}

van Kan, Gabor Abelian ^{[1
,2
]}

Vellas, Bruno ^{[1
,2
]}

机构：

[1] Univ Toulouse 3, Inserm U1027, F-31073 Toulouse, France

[2] CHU Purpan, F-31300 Toulouse, France

[3] Univ Cattolica Sacro Cuore, Dept Gerontol & Geriatr, I-00168 Rome, Italy

[4] St Louis VA Med Ctr, Geriatr Res Educ & Clin Ctr, St Louis, MO USA

[5] St Louis Univ, Sch Med, Div Geriatr, St Louis, MO USA

来源：

CLINICS IN GERIATRIC MEDICINE | 2011年 / 27卷 / 03期

关键词：

Sarcopenia; ACE; Testosterone; Growth hormone; Creatine; Vitamin D; Leptin; Myostatin; ANGIOTENSIN-CONVERTING-ENZYME; SKELETAL-MUSCLE MASS; HORMONE REPLACEMENT THERAPY; VITAMIN-D DEFICIENCY; HUMAN GROWTH-HORMONE; QUALITY-OF-LIFE; FACTOR-KAPPA-B; ANDROGEN RECEPTOR MODULATORS; POLYUNSATURATED FATTY-ACIDS; BODY-COMPOSITION;

D O I：

10.1016/j.cger.2011.03.008

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Sarcopenia is a complex multifactorial condition that can by treated with multimodal approaches. No pharmacologic agent to prevent or treat sarcopenia has been as efficacious as exercise (mainly resistance training) in combination with nutritional intervention (adequate protein and energy intake). However, performing resistance training sessions and following nutritional advice can be challenging, especially for frail, sarcopenic, elderly patients, and results remain only partial. Therefore, new pharmacologic agents may substantially reduce the functional decline in older people. This article reviews the new pharmacologic agents currently being assessed for treating sarcopenia.

引用

页码：423 / +

页数：26

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