GvHD risk assessment in hematopoietic stem cell transplantation:: Role of cytokine gene polymorphisms and an in vitro human skin explant model

被引：22

作者：

Dickinson, AM

Cavet, J

Cullup, H

Wang, XN

Sviland, L

Middleton, PG

机构：

[1] Univ Newcastle Upon Tyne, Dept Haematol, Royal Victoria Infirm, Tyneside Leukaemia Res Lab, Newcastle Upon Tyne, Tyne & Wear, England

[2] Haukeland Hosp, Avdeling Patol, Bergen, Norway

[3] Univ Newcastle, Leukaemia Res Fund Labs, Sch Med, Newcastle Upon Tyne, Tyne & Wear, England

来源：

HUMAN IMMUNOLOGY | 2001年 / 62卷 / 11期

关键词：

cytokine gene polymorphisms; predicting GvHD; in vitro human skin explant model;

D O I：

10.1016/S0198-8859(01)00324-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This present review concentrates on the recent results investigating the role of certain cytokine gene polymorphisms, including tumor necrosis factor a, interferon gamma, interleukin-6 (IL-6), IL-10, and IL-1 receptor antagonist, in allogeneic stem cell transplantation. The review discusses their potential role in predicting outcome and the development of a genetic risk index for graft-versus-host disease in human leukocyte antigen matched sibling transplants. By the comparative use of an in vitro human skin explant model, initial results suggest that certain polymorphisms may be associated with more severe disease. (C) American Society for Histocompatibility and Immunogenetics, 2001. Published by Elsevier Science Inc.

引用

页码：1266 / 1276

页数：11

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