Interleukin-18 enhances a Th2 biased response and susceptibility to Leishmania mexicana in BALB/c mice

被引：30

作者：

Bryson, Karen Jane ^{[1
]}

Wei, Xiao-Qing ^{[2
]}

Alexander, James ^{[1
]}

机构：

[1] Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow G4 0NR, Lanark, Scotland

[2] Cardiff Univ, Dept Dent Hlth & Biol Sci, Cardiff, S Glam, Wales

来源：

MICROBES AND INFECTION | 2008年 / 10卷 / 07期

关键词：

interleukin-18; Leishmania mexicana; Th2;

D O I：

10.1016/j.micinf.2008.03.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin-18 deficient mice on a BALB/c background display increased resistance to cutaneous infection with Leishmania mexicana, with reduced lesion progression and reduced parasite burdens compared with wild-type mice. Infected IL-18(-/-) mice had lower antigen specific IgG1 levels and total IgE levels and conversely higher antigen specific IgG2a levels than similarly infected wild-type mice. Splenocytes isolated from infected IL-18(-/-) mice produced significantly lower levels of antigen induced IL-4 and higher levels of IFN-gamma than wild-type animals. Consequently IL-18 during L. mexicana infection of BALB/c mice promotes a Th2 biased response and thereby has a disease exacerbating role. (C) 2008 Elsevier Masson SAS. All rights reserved.

引用

页码：834 / 839

页数：6

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