The biology of a chronic obstructive pulmonary disease exacerbation

被引：27

作者：

Hurst, John R. ^{[1
]}

Wedzicha, Jadwiga A. ^{[1
]}

机构：

[1] UCL Royal Free Hosp, Royal Free & Univ Coll Med Sch, Acad Unit Resp Unit, London NW3 2PF, England

来源：

CLINICS IN CHEST MEDICINE | 2007年 / 28卷 / 03期

关键词：

D O I：

10.1016/j.ccm.2007.05.003

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Much of the morbidity and mortality in chronic obstructive pulmonary disease relates to symptomatic deteriorations in respiratory health termed exacerbations. Exacerbations also are associated with changes in lung function and both airway and systemic inflammation. The most common causes of exacerbation are micro-organisms: respiratory viruses such as rhinovirus, and various bacterial species. This article reviews and discusses current understanding of the biology of exacerbations, considering the definition, epidemiology, etiology, and the nature and evolution of the changes in symptoms, lung function, and inflammation that characterize these important events.

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页码：525 / +

页数：13

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