Quantitative expression analysis of the small conductance calcium-activated potassium channels, SK1, SK2 and SK3, in human brain

被引：39

作者：

Rimini, R ^{[1
]}

Rimland, JM ^{[1
]}

Terstappen, GC ^{[1
]}

机构：

[1] GlaxoWellcome Med Res Ctr, Dept Biol, Mol Biol & Biochem Unit, I-37135 Verona, Italy

来源：

MOLECULAR BRAIN RESEARCH | 2000年 / 85卷 / 1-2期

关键词：

small conductance calcium-activated potassium channel; SK channel; quantitative PCR; expression; human brain;

D O I：

10.1016/S0169-328X(00)00255-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Small conductance calcium-activated potassium (SK) channels are important in controlling neuronal excitability and three SK channels have been identified to date. In the present study, we report the first quantitative analysis of SK1, SK2 and SK3 expression in human brain using TaqMan RT-PCR on a range of human brain and peripheral tissue samples. SK1 expression is restricted to the brain whereas SK2 and SK3 are more widely expressed. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：218 / 220

页数：3

共 7 条

[1] Inhibition of apamin-sensitive calcium dependent potassium channels facilitate the induction of long-term potentiation in the CA1 region of rat hippocampus in vitro [J].

Behnisch, T ;

Reymann, KG .

NEUROSCIENCE LETTERS, 1998, 253 (02) :91-94

[2] Small-conductance, calcium-activated potassium channels from mammalian brain [J].

Kohler, M ;

Hirschberg, B ;

Bond, CT ;

Kinzie, JM ;

Marrion, NV ;

Maylie, J ;

Adelman, JP .

SCIENCE, 1996, 273 (5282) :1709-1714

[3] CALCIUM-DEPENDENT CURRENT GENERATING THE AFTERHYPERPOLARIZATION OF HIPPOCAMPAL-NEURONS [J].

LANCASTER, B ;

ADAMS, PR .

JOURNAL OF NEUROPHYSIOLOGY, 1986, 55 (06) :1268-1282

[4] EFFECT OF APAMIN, A TOXIN THAT INHIBITS CA2+-DEPENDENT K+ CHANNELS, ON LEARNING AND MEMORY PROCESSES [J].

MESSIER, C ;

MOURRE, C ;

BONTEMPI, B ;

SIF, J ;

LAZDUNSKI, M ;

DESTRADE, C .

BRAIN RESEARCH, 1991, 551 (1-2) :322-326

[5]

Norris CM, 1998, J NEUROSCI, V18, P3171

[6] Differential distribution of three Ca2+-activated K+ channel subunits, SK1, SK2, and SK3, in the adult rat central nervous system [J].

Stocker, M ;

Pedarzani, P .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2000, 15 (05) :476-493

[7] Mechanism of calcium gating in small-conductance calcium-activated potassium channels [J].

Xia, XM ;

Fakler, B ;

Rivard, A ;

Wayman, G ;

Johnson-Pais, T ;

Keen, JE ;

Ishii, T ;

Hirschberg, B ;

Bond, CT ;

Lutsenko, S ;

Maylie, J ;

Adelman, JP .

NATURE, 1998, 395 (6701) :503-507

← 1 →