Slow sites in an exclusion process with limited resources

被引：12

作者：

Brackley, Chris A. ^{[1
]}

Romano, M. Carmen ^{[1
,2
]}

Thiel, Marco ^{[1
]}

机构：

[1] Univ Aberdeen, SUPA, Inst Complex Syst & Math Biol, Aberdeen AB24 3UE, Scotland

[2] Univ Aberdeen, Inst Med Sci, Aberdeen AB25 2ZD, Scotland

来源：

PHYSICAL REVIEW E | 2010年 / 82卷 / 05期

基金：

英国生物技术与生命科学研究理事会;

关键词：

TRANSFER-RNA SYNTHETASE; DRIVEN LATTICE GASES; PHASE-TRANSITIONS; ESCHERICHIA-COLI; CODON USAGE; TRANSLATION; MODEL; EFFICIENCY; RESIDUES;

D O I：

10.1103/PhysRevE.82.051920

中图分类号：

O35 [流体力学]; O53 [等离子体物理学];

学科分类号：

070204 ; 080103 ; 080704 ;

摘要：

We introduce slow bottleneck sites into a recent extension of the totally asymmetric exclusion process where hopping rates are allowed to vary dynamically with the availability of resources. In the context of messenger RNA (mRNA) translation in biology, this refers to the availability of amino acid-transfer-RNA (aa-tRNA) complexes which act as the source of amino acids for protein production. We study a simple designer mRNA with a single defect codon in the center. As well as the familiar queuing behavior we also observe a regime within the queuing phase where the queue becomes less severe as the aa-tRNAs become depleted.

引用

页数：13

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